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The Therapeutic Usage of Natural Product-Derived Medicine in Oxidative Stress-Induced Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (31 August 2020) | Viewed by 6598

Special Issue Editor

Dr. Soochan Bae

E-Mail Website
Guest Editor
Beth Israel Deaconess Medical Center, Cardiovascular Institute, 3 Blackfan Circle, CLS 910, Boston, MA 02215, USA
Interests: oxidative stress; nanotherapy; apoptosis; inflammation; natural products; cardiovascular diseases

Special Issue Information

Dear colleagues,

Overactive oxidative processes have been implicated in a myriad of diseases and injuries, including ischemia/reperfusion injury, inflammation, autoimmune diseases, cancer, diabetes, lung injury, neurodegenerative diseases, and cardiovascular diseases. When cells experience oxidative stress, there is an excessive production of reactive oxygen species (ROS), which could lead to irreversible damages due to the release of pro-inflammatory cytokine and the initiation of cell death. Therefore, suppressing oxidative stress by decreasing the level of ROS is a therapeutically relevant approach for a variety of diseases.

Recently, a number of natural product-derived drugs have shown various benefits in combating ROS overproduction. Due to their fewer side effects compared to most conventional therapies, the use of natural product-derived medicine together with other biodegradable synthetic particles, such as nanoparticles, for targeted therapy is currently under active investigation for their potential clinical applications.

This Special Issue of the International Journal of Molecular Sciences will include original research articles as well as review articles that cover various natural product-derived drugs that have assumed an essential role in preventing or treating oxidative stress-induced diseases. It is now open for submission. We encourage your contribution to this Special Issue.

Dr. Soochan Bae
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural products
  • oxidative stress
  • inflammation
  • therapeutic effect

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Published Papers (2 papers)

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Research

10 pages, 508 KiB  
Article
Corneal UV Protective Effects of a Topical Antioxidant Formulation: A Pilot Study on In Vivo Rabbits
by Marisa Palazzo, Francesco Vizzarri, Lubomir Ondruška, Michele Rinaldi, Luigi Pacente, Germano Guerra, Francesco Merolla, Ciro Caruso and Ciro Costagliola
Int. J. Mol. Sci. 2020, 21(15), 5426; https://doi.org/10.3390/ijms21155426 - 30 Jul 2020
Cited by 8 | Viewed by 2351
Abstract
This study aimed to evaluate the protective effect of a topical antioxidant and ultraviolet (UV) shielding action formulation containing riboflavin and D-α-tocopherol polyethylene glycol succinate (TPGS) vitamin E against corneal UV-induced damage in vivo rabbit eyes. In vivo experiments were performed using male [...] Read more.
This study aimed to evaluate the protective effect of a topical antioxidant and ultraviolet (UV) shielding action formulation containing riboflavin and D-α-tocopherol polyethylene glycol succinate (TPGS) vitamin E against corneal UV-induced damage in vivo rabbit eyes. In vivo experiments were performed using male albino rabbits, which were divided into four groups. The control group (CG) did not receive any UV irradiation; the first group (IG) was irradiated with a UV-B−UV-A lamp for 30 min; the second (G30) and third (G60) groups received UV irradiation for 30 and 60 min, respectively, and were topically treated with one drop of the antioxidant and shielding formulation every 15 min, starting one hour before irradiation, until the end of UV exposure. The cornea of the IG group showed irregular thickening, detachment of residual fragments of the Descemet membrane, stromal fluid swelling with consequent collagen fiber disorganization and disruption, and inflammation. The cornea of the G30 group showed edema, a mild thickening of the Descemet membrane without fibrillar collagen disruption and focal discoloration, or inflammation. In the G60 group, the cornea showed a more severe thickening, a more abundant fluid accumulation underneath the Descemet membrane with focal detachment, and no signs of severe tissue alterations, as were recorded in the IG group. Our results demonstrate that topical application of eye drops containing riboflavin and TPGS vitamin E counteracts UV corneal injury in exposed rabbits. Full article
(This article belongs to the Special Issue The Therapeutic Usage of Natural Product-Derived Medicine in Oxidative Stress-Induced Diseases)
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19 pages, 4608 KiB  
Article
Molecular Rescue of Dyrk1A Overexpression Alterations in Mice with Fontup® Dietary Supplement: Role of Green Tea Catechins
by Yuchen Gu, Gautier Moroy, Jean-Louis Paul, Anne-Sophie Rebillat, Mara Dierssen, Rafael de la Torre, Cécile Cieuta-Walti, Julien Dairou and Nathalie Janel
Int. J. Mol. Sci. 2020, 21(4), 1404; https://doi.org/10.3390/ijms21041404 - 19 Feb 2020
Cited by 16 | Viewed by 3920
Abstract
Epigallocatechin gallate (EGCG) is an inhibitor of DYRK1A, a serine/threonine kinase considered to be a major contributor of cognitive dysfunctions in Down syndrome (DS). Two clinical trials in adult patients with DS have shown the safety and efficacy to improve cognitive phenotypes using [...] Read more.
Epigallocatechin gallate (EGCG) is an inhibitor of DYRK1A, a serine/threonine kinase considered to be a major contributor of cognitive dysfunctions in Down syndrome (DS). Two clinical trials in adult patients with DS have shown the safety and efficacy to improve cognitive phenotypes using commercial green tea extract containing EGCG (45% content). In the present study, we performed a preclinical study using FontUp®, a new nutritional supplement with a chocolate taste specifically formulated for the nutritional needs of patients with DS and enriched with a standardized amount of EGCG in young mice overexpressing Dyrk1A (TgBACDyrk1A). This preparation is differential with previous one used, because its green tea extract has been purified to up 94% EGCG of total catechins. We analyzed the in vitro effect of green tea catechins not only for EGCG, but for others residually contained in FontUp®, on DYRK1A kinase activity. Like EGCG, epicatechin gallate was a noncompetitive inhibitor against ATP, molecular docking computations confirming these results. Oral FontUp® normalized brain and plasma biomarkers deregulated in TgBACDyrk1A, without negative effect on liver and cardiac functions. We compared the bioavailability of EGCG in plasma and brain of mice and have demonstrated that EGCG had well crossed the blood-brain barrier. Full article
(This article belongs to the Special Issue The Therapeutic Usage of Natural Product-Derived Medicine in Oxidative Stress-Induced Diseases)
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