Progress in Research on Endocrine-Disrupting Chemicals
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: 30 November 2024 | Viewed by 295
Special Issue Editor
Special Issue Information
Dear Colleagues,
Endocrine-Disrupting Chemicals (EDCs) are artificial compounds that intervene in normal hormone functions through agonistic, antagonistic or disruptive effects. Their actions extend from humans to many other species and are characterized by non-monotonic effects in multiple systems of the exposed organism, as well as transgenerational transfer. Experimental and epidemiological studies indicate that early life exposures are considered more harmful and life-long due to immature defence mechanisms of the organisms, though exposures in adulthood can also have adverse outcomes. Research on the impact of single EDCs has contributed to our understanding of the targets and mechanisms of action of these chemicals. However, it has been shown that co-exposure to more than one EDC can have different effects, compared to single exposures. Nowadays, it is thus well accepted that investigation of the impact of epidemiology-based mixtures of EDCs, instead of single chemicals, is closer to real life conditions. Knowledge on EDCs is rapidly expanding to all aforementioned directions. This Issue aims to provide recent evidence from both cohort studies and experimental models on EDCs or their mixtures, regarding their biomonitoring, target tissues, mechanisms of action, and risk assessment approaches.
Prof. Dr. Efthymia Kitraki
Guest Editor
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Keywords
- Endocrine-Disrupting Chemicals (EDCs)
- chemical mixtures
- biomonitoring
- cohort studies
- in vivo and in vitro models
- mechanisms of action
- risk assessment
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