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Molecular and Cellular Mechanisms in Reproduction

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 31 January 2025 | Viewed by 1811

Special Issue Editors


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Guest Editor
Department of Stem Cell and Regenerative Biotechnology, Konkuk Institute of Technology, Konkuk University, Seoul 05029, Republic of Korea
Interests: uterine biology; germ cell development; regeneration; aging; infertility
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Gangnam CHA Fertility Center, CHA University, 566, Nonhyeon-ro, Gangnam-gu, Seoul, Republic of Korea
Interests: uterine biology; infertility; ovarian aging; endometrial regeneration

Special Issue Information

Dear Colleagues,

For species conservation, it is very important to understand the reproductive process and mechanisms. Unlike other organs, reproductive organs such as testes, ovaries, and uterus are regulated very accurately periodically after puberty. In mammals, including humans, germ cells undergo meiosis after development and must undergo special cell division to differentiate into mature haploid germ cells, sperm, and eggs. These sperm and eggs are fertilized and implanted in the endometrium to produce healthy offspring. A very complex process is carried out dynamically until birth. However, there are still many unknown aspects in these regards. Therefore, through this Special Issue we wish to cover topics that will allow us to gain a deeper understanding of the series of reproductive processes that are not yet well known and to obtain insights into overcoming unexplained infertility in the future. Therefore, I hope that many scientists interested in these topics will respond positively.

Prof. Dr. Youngsok Choi
Dr. Eun Mi Chang
Guest Editors

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Keywords

  • mammalian reproduction
  • uterine biology
  • oogenesis
  • spermatogenesis
  • meiosis
  • embryo development
  • uterine implantation
  • endometrial regeneration
  • ovarian aging
  • endometriosis
  • ovarian cancer
  • testicular cancer
  • uterine cancer
  • cervical cancer
  • menopause

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Published Papers (1 paper)

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Review

19 pages, 354 KiB  
Review
Endocrine-Disrupting Chemicals, Hypothalamic Inflammation and Reproductive Outcomes: A Review of the Literature
by Galateia Stathori, Kyriaki Hatziagapiou, George Mastorakos, Nikolaos F. Vlahos, Evangelia Charmandari and Georgios Valsamakis
Int. J. Mol. Sci. 2024, 25(21), 11344; https://doi.org/10.3390/ijms252111344 - 22 Oct 2024
Viewed by 1565
Abstract
Endocrine-disrupting chemicals (EDCs) are environmental and industrial agents that interfere with hormonal functions. EDC exposure is linked to various endocrine diseases, especially in reproduction, although the mechanisms remain unclear and effects vary among individuals. Neuroinflammation, particularly hypothalamic inflammation, is an emerging research area [...] Read more.
Endocrine-disrupting chemicals (EDCs) are environmental and industrial agents that interfere with hormonal functions. EDC exposure is linked to various endocrine diseases, especially in reproduction, although the mechanisms remain unclear and effects vary among individuals. Neuroinflammation, particularly hypothalamic inflammation, is an emerging research area with implications for endocrine-related diseases like obesity. The hypothalamus plays a crucial role in regulating reproduction, and its inflammation can adversely affect reproductive health. EDCs can cross the blood–brain barrier, potentially causing hypothalamic inflammation and disrupting the reproductive axis. This review examines the existing literature on EDC-mediated hypothalamic inflammation. Our findings suggest that exposure to 2,3,7,8-tetrachloro-dibenzo-p-dioxin (TCDD), polychlorinated biphenyl (PCB), tributyltin (TBT), phthalates, bisphenol A (BPA), and chlorpyrifos (CPF) in animals is linked to hypothalamic inflammation, specifically affecting the hypothalamic centers of the gonadotropic axis. To our knowledge, this is the first comprehensive review on this topic, indicating hypothalamic inflammation as a possible mediator between EDC exposure and reproductive dysfunction. Further human studies are needed to develop effective prevention and treatment strategies against EDC exposure. Full article
(This article belongs to the Special Issue Molecular and Cellular Mechanisms in Reproduction)
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