Therapeutic Strategy for Pathological Cardiac Hypertrophy

Dear Colleagues,

Pathological cardiac hypertrophy is a key risk factor for heart failure. Increased interstitial fibrosis, cardiac dysfunction and cell death are essential features of pathological cardiac hypertrophy. The numerous mediators that have been found as involved in the pathogenesis of maladaptive heart growth can affect gene transcription, calcium handling, protein synthesis, metabolism, mitochondrial function, autophagy, oxidative stress and inflammation. Many of the molecular mechanisms and dysregulated signaling pathways implicated in promoting malignant remodeling have been unrevealed. Focusing on these key regulation points seems to be an important target for defining innovative strategies for the management of pathological hypertrophy.

This special issue aims to take stock of advances in the development and validation of therapeutic strategies against pathological cardiac hypertrophy, both in preclinical and clinical studies. Research papers and up-to-date review articles are all welcome on various topics including, but not limited to, either conventional drug strategies or novel therapeutic approaches (e.g., RNA-based therapies, dietary supplementation, drug delivery systems) targeting molecular pathways involved in the transition to hypertrophic maladaptive remodeling of the heart.

Dr. Claudia Kusmic
Guest Editor

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