Pharmacologic Targeting of the Tumor Microenvironment
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (30 June 2021) | Viewed by 70968
Special Issue Editor
Interests: tumor microenvironment; cell–cell signaling; cell metabolism; hypoxia; oxidative stress; drug repurposing; ovarian cancer; breast cancer
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Progress in our understanding of the complex composition of the tumor microenvironment has revealed the critical influence of stromal cells (e.g., fibroblasts, adipocytes, endothelial cells) in the ability of tumors to rapidly grow and metastasize to secondary tissues. Recent research has identified novel signaling mechanisms by which tumor–stroma interactions, in part due to signals emanating from stromal cells, facilitate key mechanisms involved in tumor cell proliferation, clonogenicity, migration, adhesion, and invasion. These interactions potentially provide a new set of therapeutic liabilities to target pharmacologically, to refine clinical strategies, and ultimately to improve patient outcomes. Here, in this Special Issue on “Pharmacologic Targeting of the Tumor Microenvironment”, we shall discuss the ability of repurposed and novel compounds to modulate tumor–stroma interactions with a focus on the efficacy of pharmacologic agents to impede bidirectional signaling mechanisms required for tumor development and metastatic progression.
This issue of the International Journal of Molecular Sciences is open to both original research articles and review articles focusing on advances in preclinical evaluation of pharmacologic approaches to modulate the tumor microenvironment in order to inhibit cancer progression.
Dr. Peter C. Hart
Guest Editor
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Keywords
- tumor microenvironment
- stroma
- fibroblast
- adipocyte
- leukocyte
- endothelial cell
- metastasis
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