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Lipidomics and Lipid Metabolism in Health and Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 2183

Special Issue Editor


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Guest Editor
1. Friedman Diabetes Institute, Lenox Hill Hospital, Northwell Health, New York, NY 10022, USA
2. Feinstein Institutes for Medical Research, Hempstead, NY 11030, USA
3. Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY 11549, USA
Interests: adipose tissue; obesity; inflammation; diabetes; breast cancer
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Special Issue Information

Dear Colleagues,

Lipids play critical roles in numerous biological processes, ranging from cellular signaling and energy storage to membrane structure and function. Advances in lipidomics and our understanding of lipid metabolism continue to develop the complex regulation of lipid homeostasis in health and disease. This Special Issue highlights the latest research on lipid metabolism and lipidomics. We invite submissions of original research articles and reviews covering a range of topics related to lipids, including, but not limited to, the following:

  • Lipid signaling pathways and networks;
  • Lipid–protein interactions;
  • Regulation of lipid synthesis, transport, and catabolism;
  • Lipid metabolism in metabolic diseases such as obesity, diabetes, and cardiovascular disease;
  • Lipidomics technologies and analytical methods;
  • Lipid biomarkers and therapeutic targets.

We look forward to receiving your contributions to this Special Issue.

Dr. Dimiter Avtanski
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lipidomics
  • lipid metabolism
  • lipid signaling
  • lipid homeostasis
  • metabolic disease
  • lipid biomarkers
  • fatty acids
  • phospholipids
  • sphingolipids
  • cholesterol

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Published Papers (1 paper)

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Review

16 pages, 1751 KiB  
Review
Adipose Tissue Dysfunction Related to Climate Change and Air Pollution: Understanding the Metabolic Consequences
by Radoslav Stojchevski, Preethi Chandrasekaran, Nikola Hadzi-Petrushev, Mitko Mladenov and Dimiter Avtanski
Int. J. Mol. Sci. 2024, 25(14), 7849; https://doi.org/10.3390/ijms25147849 - 18 Jul 2024
Viewed by 1938
Abstract
Obesity, a global pandemic, poses a major threat to healthcare systems worldwide. Adipose tissue, the energy-storing organ during excessive energy intake, functions as a thermoregulator, interacting with other tissues to regulate systemic metabolism. Specifically, brown adipose tissue (BAT) is positively associated with an [...] Read more.
Obesity, a global pandemic, poses a major threat to healthcare systems worldwide. Adipose tissue, the energy-storing organ during excessive energy intake, functions as a thermoregulator, interacting with other tissues to regulate systemic metabolism. Specifically, brown adipose tissue (BAT) is positively associated with an increased resistance to obesity, due to its thermogenic function in the presence of uncoupled protein 1 (UCP1). Recently, studies on climate change and the influence of environmental pollutants on energy homeostasis and obesity have drawn increasing attention. The reciprocal relationship between increasing adiposity and increasing temperatures results in reduced adaptive thermogenesis, decreased physical activity, and increased carbon footprint production. In addition, the impact of climate change makes obese individuals more prone to developing type 2 diabetes mellitus (T2DM). An impaired response to heat stress, compromised vasodilation, and sweating increase the risk of diabetes-related comorbidities. This comprehensive review provides information about the effects of climate change on obesity and adipose tissue, the risk of T2DM development, and insights into the environmental pollutants causing adipose tissue dysfunction and obesity. The effects of altered dietary patterns on adiposity and adaptation strategies to mitigate the detrimental effects of climate change are also discussed. Full article
(This article belongs to the Special Issue Lipidomics and Lipid Metabolism in Health and Disease)
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