Molecular Regulators of Cardiovascular Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 5076
Special Issue Editor
Special Issue Information
Dear Colleagues,
Endotheliopathy plays a role in of the development of organ failure in critically ill patients. During hyperinflammatory conditions that can occur in acute critical illness, such as shock or hypoperfusion, inflammatory mediators activate the endothelium, fueling a proinflammatory host response and procoagulant processes. These changes result in shedding of the glycocalyx, endothelial hyperpermeability and edema formation, and can lead to disturbed microcirculatory perfusion and organ failure. Targeting the endothelium may be a therapeutic strategy to limit organ failure, which hitherto has not received much attention.
Although therapeutic targeting of several molecular pathways seems promising in terms of restoring the endothelium in critical illness, only minor treatments have made it to the clinic. Therefore, more studies are required in order for us to understand the development of endotheliopathy and to improve therapeutic strategies.
We invite scientists and researchers to contribute original research and review articles which provide insight into (new) molecular mechanisms related to the regulation of the endothelium and the development of endotheliopathy.
Dr. Charissa E. Van Den Brom
Guest Editor
Manuscript Submission Information
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Keywords
- endotheliopathy
- criticall illness
- microcirculation
- molecular mechanism
- coagulation
- endothelial barrier function
- glycocalyx
- edema
- organ injury
