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Molecular Study of Renal Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 September 2024 | Viewed by 617

Special Issue Editors


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Guest Editor
Bicocca Bioinformatics Biostatistics and Bioimaging B4 Center, Department of Medicine and Surgery, University of Milan-Bicocca, 20900 Monza, Italy
Interests: biostatistics; supervised and unsupervised statistical methods; artificial intelligence; spatial OMICS; single-cells analysis; multi-omics integration
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Guest Editor
Department of Medicine and Surgery, Pathology, University of Milan-Bicocca, San Gerardo Hospital, 20126 Milano, MI, Italy
Interests: renal pathology; glomerulonephritis; proteomics; autoimmunity; molecular pathology; digital pathology; lymphoma
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy
Interests: epidemiology, prognosis and treatment of chronic kidney disease patients; cardiovascular risk; kidney transplant; hemodialysis; peritoneal dialysis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Chronic kidney disease (CKD) is progressively increasing in incidence and represents an important economic burden for health systems and a significant discomfort for patients, often leading to end-stage kidney disease (ESKD) whose only therapeutic approaches are still represented by renal replacement therapies (RRTs). To help slowing down the progression of CKD and the comprehension of the underlying mechanisms leading to ESKD the application of alternative computational, digital and omic tools represents an invaluable resource applicable on different media (renal biopsy, blood, urine) to unveil the pathobiological basis of renal diseases. This can prompt (1) the detection of new diagnostic, prognostic and predictive biomarkers easily translatable to the clinical practice, (2) detect new putative targets for innovative therapies in the precision medicine direction and (3) understand the molecular modifications leading to the perturbation of renal homeostasis.

In this setting, we are opening the invitation to submit your research in this Special Issue, entitled "Computational, Digital and Spatial Biology Tools for the Study of Renal Diseases", which aims to provide a research platform for the collection of original research articles and the latest reviews which cover all molecular aspects of kidney diseases.

Dr. Giulia Capitoli
Dr. Vincenzo L'Imperio
Dr. Michele Provenzano
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • digital pathology
  • computational pathology
  • spatial biology
  • renal biopsy
  • chronic kidney disease

Published Papers (1 paper)

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Research

18 pages, 9633 KiB  
Article
Characterizing Glomerular Barrier Dysfunction with Patient-Derived Serum in Glomerulus-on-a-Chip Models: Unveiling New Insights into Glomerulonephritis
by Shin Young Kim, Yun Yeong Choi, Eun Jeong Kwon, Seungwan Seo, Wan Young Kim, Sung Hyuk Park, Seokwoo Park, Ho Jun Chin, Ki Young Na and Sejoong Kim
Int. J. Mol. Sci. 2024, 25(10), 5121; https://doi.org/10.3390/ijms25105121 - 8 May 2024
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Abstract
Glomerulonephritis (GN) is characterized by podocyte injury or glomerular filtration dysfunction, which results in proteinuria and eventual loss of kidney function. Progress in studying the mechanism of GN, and developing an effective therapy, has been limited by the absence of suitable in vitro [...] Read more.
Glomerulonephritis (GN) is characterized by podocyte injury or glomerular filtration dysfunction, which results in proteinuria and eventual loss of kidney function. Progress in studying the mechanism of GN, and developing an effective therapy, has been limited by the absence of suitable in vitro models that can closely recapitulate human physiological responses. We developed a microfluidic glomerulus-on-a-chip device that can recapitulate the physiological environment to construct a functional filtration barrier, with which we investigated biological changes in podocytes and dynamic alterations in the permeability of the glomerular filtration barrier (GFB) on a chip. We also evaluated the potential of GN-mimicking devices as a model for predicting responses to human GN. Glomerular endothelial cells and podocytes successfully formed intact monolayers on opposite sides of the membrane in our chip device. Permselectivity analysis confirmed that the chip was constituted by a functional GFB that could accurately perform differential clearance of albumin and dextran. Reduction in cell viability resulting from damage was observed in all serum-induced GN models. The expression of podocyte-specific marker WT1 was also decreased. Albumin permeability was increased in most models of serum-induced IgA nephropathy (IgAN) and membranous nephropathy (MN). However, sera from patients with minimal change disease (MCD) or lupus nephritis (LN) did not induce a loss of permeability. This glomerulus-on-a-chip system may provide a platform of glomerular cell culture for in vitro GFB in formation of a functional three-dimensional glomerular structure. Establishing a disease model of GN on a chip could accelerate our understanding of pathophysiological mechanisms of glomerulopathy. Full article
(This article belongs to the Special Issue Molecular Study of Renal Diseases)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Planned Paper I: Kidney diseases and cardiovbascular disease, involving vitamin K deficiency, matrix gla protein and pulse wave velocity

Planned Paper II: The Mathematical Analysis of the Contrast-Enhanced CT of the Kidneys in the Patients with Urolithiasis

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