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Molecular Mechanisms of Oxidative Stress in Kidney Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 March 2025 | Viewed by 1433

Special Issue Editor


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Guest Editor
Division of Nephrology and Hypertension, 1st Department of Internal Medicine, Medical School, AHEPA Hospital, Aristotle University, 57001 Thessaloniki, Greece
Interests: CKD; hemodialysis; oxidative stress; vitamin K; diabetic nephropathy; vascular calcification; CVD; matrix GLA protein
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Special Issue Information

Dear Colleagues,

In recent years, oxidative stress (OS) has emerged as a novel player in chronic conditions. In chronic kidney disease (CKD), OS starts early, gradually increases in parallel with deterioration of kidney function and is further exacerbated in end-stage kidney disease by renal replacement modalities. In these patients, OS underlies the progression of CKD and contributes to the onset and development of atherosclerosis. As such, it is crucial to diagnose OS early and find strategies to ameliorate its deleterious effects. In this Special Issue, we will study the impact of OS in CKD at a molecular level. Researchers are encouraged to submit reviews and research articles focused on the association between molecules/markers of OS and inflammation, atherosclerosis and CKD. Antioxidant molecules and other markers involved in this pathophysiologic pathway could also be studied.

Dr. Stefanos Roumeliotis
Guest Editor

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Keywords

  • chronic kidney disease
  • end-stage kidney disease
  • hemodialysis
  • peritoneal dialysis
  • oxidative stress
  • pro-oxidants
  • inflammation
  • atherosclerosis
  • cardiovascular disease

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Published Papers (1 paper)

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Research

17 pages, 4167 KiB  
Article
Urtica dioica L. Leaf Extract Dose-Dependently Modulates Oxidative Stress in the Kidney and Exerts Anti-Fibrotic and Anti-Inflammatory Properties by the Molecular Mechanisms Independent of NRF-2 Signalization Mirroring the Effects of Losartan in SHR
by Una-Jovana Vajic, Nevena Mihailovic-Stanojevic, Danijela Karanovic, Maja Zivotic, Milan Ivanov, Djurdjica Jovovic, Jelica Grujic-Milanovic and Zoran Miloradovic
Int. J. Mol. Sci. 2024, 25(24), 13272; https://doi.org/10.3390/ijms252413272 - 11 Dec 2024
Viewed by 666
Abstract
Previously, we confirmed systemic antihypertensive and antioxidant properties of Urtica dioica L. leaf extract (UE) in spontaneously hypertensive rats (SHR). Here, we aimed to evaluate whether UE can alter the NO and Nrf-2 signaling to prevent local oxidative stress and kidney damage in [...] Read more.
Previously, we confirmed systemic antihypertensive and antioxidant properties of Urtica dioica L. leaf extract (UE) in spontaneously hypertensive rats (SHR). Here, we aimed to evaluate whether UE can alter the NO and Nrf-2 signaling to prevent local oxidative stress and kidney damage in the model of essential hypertension. SHR were divided into five groups: SHRC-control, received 0.5 mL/day of water, SHR+L received 10 mg/kg/day of losartan, SHR+UE10, SHR+UE50, and SHR+UE200 received 10, 50, and 200 mg/kg/day during next 4 weeks. At the end of the experiment, urine samples were collected for albuminuria and nitrate/nitrite assessment. Mean arterial pressure (MAP) was measured, and blood samples were collected for plasma creatinine evaluation. Kidneys were analyzed for nitrate/nitrite, oxidative stress, and target molecules by biochemical, Western blot, and immunofluorescent techniques. Losartan and UE50 significantly reduced MAP, albuminuria, oxidative stress, fibroinflammatory markers, and NRF-2/CAT/SOD signaling, with a significant increase in 6-nitrotryptophan and eNOS expressions compared to control. The effects of UE showed dose dependence. Beneficial effects of UE and losartan were independent of NRF-2 signalization in SHR. Interestingly, all treatments induced the increase in 6-nitrotryptophan expression, thus further studies are needed to elucidate the mechanisms of such nitrated tryptophan. Full article
(This article belongs to the Special Issue Molecular Mechanisms of Oxidative Stress in Kidney Disease)
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