Etiology and Pathogenesis of Pulpitis and Apical Periodontitis 2023
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (1 April 2024) | Viewed by 2300
Special Issue Editor
Interests: nanoparticles; wound healing; inorganic nanoparticles; drug delivery systems
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The apical periodontitis is an infection-driven, chronic inflammatory disease, which usually leads to the destruction of periodontal tissues, the alveolar bone, and impaired dentition. Uncontrolled infection of periapical tissues through a bacterial infection in the root canal might result in extensive bone resorption around the root that ultimately leads to tooth loss if left untreated. Therefore, pulpitis and apical periodontitis impact a patient’s quality of life and cause significant burdens.
The apical periodontitis occurs due to the long-term infection and pathogenic irritants in the root canal. These bacteria inhabit anatomical locations that are inaccessible to macrophages and other immune cells, such as dentin tubules, thus creating conditions for bacteria to directly damage tissue and secrete enzymes, exotoxins, and metabolic end products to regulate the immune response. The presence of microbial factors stimulates an immune response, producing a series of pathological manifestations, mainly inflammation affecting the bone tissue. Thus, its pathogenesis, prevention and treatment are a challenge for the clinicians. During treatment, infection control should be resolved first, and periapical bone remodeling should be carried out on this basis.
The aim of the present Special Issue is to gather manuscripts (original articles and reviews) that address questions related to the pulpitis and apical periodontitis physiopathology, ranging from the pathogenesis to the therapeutic approaches in animal models and/or clinical trials.
Dr. Rafael Scaf De Molon
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
