SGLT2 Inhibitors: Emerging "Magic Bullets" beyond Glycemic Control (Volume 2)
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 47332
Special Issue Editor
Interests: cardiovascular G protein-coupled receptors (GPCRs); heart failure; autonomic control of the circulation; adrenal physiology and pharmacology; adrenergic receptors; angiotensin receptors; signal transduction; gene therapy; aldosterone pharmacology; GPCR-Kinases; arrestins; G protein signaling
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue follows the publication of the first volume on “SGLT2 Inhibitors: Emerging “Magic Bullets” beyond Glycemic Control”, which presented 13 high-quality papers.
Originally developed for restoring euglycemia in diabetes mellitus, SGLT2 inhibitors (SGLT2is) are increasingly being demonstrated to exert beneficial effects in patients, extending beyond blood glucose regulation. For instance, they reduce cardiovascular disease mortality, ameliorate kidney disease progression, lower blood pressure, and confer weight loss, even in non-diabetics or in people with end-stage chronic kidney disease. Therefore, a lot of information regarding the physiological effects and pharmacological mechanisms of SGLT2is remains to be found, necessitating more research to fully grasp their therapeutic potential.
On these grounds, this Special Issue of the International Journal of Molecular Sciences is focused on studies that explore the biological and pharmacological effects of SGLT2is in human physiology and disease. Investigations with a solid basic/molecular research foundation and/or translational potential are of particular interest, including papers exploring novel molecular and cellular mechanisms underlying the effects of these drugs, as well as pre-clinical investigations testing novel hypotheses that advance the molecular and clinical pharmacology of SGLT2 inhibitors. Original investigations, review articles, and short communications will all be considered. Purely clinical investigations are not suitable, but clinical submissions with at least some component of molecular studies are quite welcome.
Suggested disease areas/topics to be covered include (but are by no means limited to) the following:
- cell biology;
- signal transduction;
- autonomic nervous system;
- atherosclerosis/lipid disorders;
- cancer;
- hypertension;
- cognitive dysfunction/neurodegeneration and other central nervous system (CNS) disorders;
- heart failure and cardiac arrhythmias;
- metabolic syndrome/diabetes mellitus;
- stem cell biology/physiology;
- inflammatory and/or autoimmune diseases and pain;
- cardiovascular endocrinology (e.g., adrenal gland and neuronal control of the circulation);
- end-organ damage and sepsis;
- respiratory diseases;
- kidney disorders;
- vascular pathologies;
- aging;
- obesity/adipose tissue biology;
- drug–drug interactions with other drug classes;
- adverse effects and toxicology;
- pharmacogenetics/pharmacogenomics;
- metabolism and pharmacokinetics in humans;
- effects in special populations (pediatric, geriatric, pregnancy, etc.);
- sex differences in drug action/response;
- cellular energetics/mitochondria;
- nuclear biology/DNA damage;
- oxidative stress.
Dr. Anastasios Lymperopoulos
Guest Editor
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Keywords
- diabetes
- glucose reduction
- metabolic disorders
- heart failure
- cardiovascular disease
- signal transduction
- kidney disease
- hypertension
- obesity
- adverse effects
- neurodegeneration
- inflammation
- adipose tissue
- pharmacokinetics
- toxicity
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