New Molecular Targets in Systemic Lupus Erythematosus and Lupus Nephritis
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 3797
Special Issue Editors
Interests: systemic lupus erythematosus; antiphospholipid syndrome; systemic sclerosis; rheumatoid arthritis; biomarkers; T lymphocytes; autoantibodies; adaptive immunity; bDMARDs
Interests: systemic lupus erythematosus; lupus nephritis; sarcoidosis; systemic sclerosis; interstitial lung disease; myositis; vasculitis; emergency medicine
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Systemic lupus erythematosus (SLE), a prototypic autoimmune disease, has seen significant advances over the recent years in terms of molecular pathways involved and a clearer understanding of the pathophysiology. In addition, new molecular targets are being developed and tested, resulting in exciting times for patients and physicians. Nevertheless, many of the developed drugs fail to demonstrate a benefit in subsequent clinical trials. The kidneys are the major organs affected by systemic autoimmune diseases, and lupus nephritis (LN) is one of the most feared complications of SLE, which considerably increasing morbidity and mortality. However, new therapeutic options have emerged with the recent approval of anifrolumab, an anti-interferon antibody, and voclosporine, a novel calcineurin inhibitor. These opportunities come with the challenge of finding their place in the therapeutic algorithms but represent a step forward toward tailoring treatment to individual patients.
This Special Issue aims to provide a forum for new research findings and reviews on the molecular pathways involved in the pathophysiology of SLE and LN, deepening our understanding of this heterogeneous and challenging disease.
We invite basic, translational and clinical scientists from all specialties involved in the research and care of SLE patients to contribute their findings to our themed issue.
Dr. Silvia Piantoni
Dr. Peter Korsten
Guest Editors
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Keywords
- systemic lupus erythematosus
- lupus nephritis
- targeted therapies
- adaptive immunity
- autoantibodies
- biomarkers
- pathophysiology
- translational research
- clinical research.
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