Cyclic Nucleotide Analogues as Biochemical Tools and Prospective Drugs
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 5012
Special Issue Editor
Interests: cellular signal transduction; interaction of cellular signaling pathways; cellular pharmacology; chronobiology; clock genes
Special Issue Information
Dear Colleagues,
Nucleotides and inositol phosphates are examples of second messengers involved in cellular events, and some analogs of this type are promising enough to be tested as drugs. Other analogs have become standard tools for the investigation of biochemical and physiological signal transduction pathways, like the Rp-diastereomers of adenosine and guanosine 3`,5`-cyclic monophosphorothioate, as competitive inhibitors of cAMP- and cGMP-dependent protein kinases. Next generation analogs exhibit a higher membrane permeability, increased resistance against degradation, and improved target specificity, or are caged or photoactivatable for fast and/or targeted cellular imaging. Novel specific nucleotide analogs activating or inhibiting cyclic nucleotide-dependent ion channels, EPAC/GEF proteins, and bacterial target molecules have been developed, opening new avenues for basic and applied research. This Special Issue will highlight recent developments in second messenger analog research, as well as comment and elaborate on seminal findings in the field in the form of technical or review papers.
Prof. Dr. Erik Maronde
Guest Editor
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Keywords
- second messenger analogs
- cAMP/cGMP
- calcium
- cAMP/cGMP-dependent protein kinase agonists
- cAMP/cGMP-dependent protein kinase antagonists
- caged second messenger analogs
- nucleotide signalling
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