Stroke: Merging Neuroprotection and Neuroregeneration towards Therapeutics 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 17855
Special Issue Editor
Interests: stem cell therapy; stroke, neonatal hypoxic-ischemic injury; Parkinson's disease; traumatic brain injury; translational research
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue will assemble stroke researchers and clinicians who have a vested interest in improving therapeutic outcomes in ischemic stroke. Although treatment options for stroke remain limited, tissue plasminogen activator or tPA and mechanical thrombectomy have seen their therapeutic windows extended to 4.5 hours and 24 hours after stroke onset, respectively. These wider times to initiate treatment intervention allow a larger population of stroke patients to benefit from these therapies. However, there remain more than 90% of stroke patients who will still be ineligible for treatment with tPA and thrombectomy. A combination of novel neuroprotective and neuroregenerative therapies, such as remote limb conditioning and localized hypothermia under the setting of tPA and thrombectomy, may further increase the therapeutic window and enhance functional outcomes in stroke. The merger of acute neuroprotection and delayed neuroregeneration represents an emerging field in stroke therapeutics. Understanding the molecular mechanisms of these therapies is the main focus of this issue.
Prof. Dr. Cesar Borlongan
Guest Editor
Manuscript Submission Information
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Keywords
- Stroke
- Neuroprotection
- Neuroregeneration