Oligonucleotide, Therapy, and Applications 3.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: closed (30 December 2022) | Viewed by 7486
Special Issue Editors
Interests: pharmacogenetics; genetic variants; non-viral vector; transfection; hydrodynamic transfection; ex vivo organ; therapeutic oligonucleotides; antisense oligonucleotides
Special Issues, Collections and Topics in MDPI journals
Interests: gene therapy; non viral; oligonucleotides; vaccines; pharmacogenetic
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Oligonucleotides (ON) constitute a new group of molecular agents, an object of significant interest due to their potential value as drugs for diagnostic and therapeutic applications. The special interest in ONs derives from their intrinsic characteristics: a) ONs are informative agents, a property that derives from the order in which the nucleotides of each particular ON are arranged. b) ONs can act as ligands (ASO, TFO, aptamers, G-quadruplex, etc.) of complementary nucleic acid sequences (DNA or RNA) due to their high capacity to hybridize (by means of Watson and Crick or Hoogsteen links) with other nucleotide sequences, resulting in specific gene modulatory effects. However, nonspecific sequences may also be of interest, as is the case with repetitive nucleotide sequences (CpG) with adjuvant effects of vaccines. c) ONs can also rapidly evolve to achieve specific advantages of utility (targeting, stability, efficacy, toxicity, etc.) or high-sensitivity diagnostic technology (markers, analyzes, biosensors, FISH, microarrays, etc.) by chemical modification of nucleotides in any of their atoms. These properties show that ONs are first-order molecules due to their potential usefulness in practice.
In this collection of research articles and review papers, we aim to highlight their therapeutic, diagnostic and technological applications as drugs.
Prof. Dr. Salvador Aliño
Dr. Luis Sendra
Guest Editors
Manuscript Submission Information
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Keywords
- oligonucleotide
- antisense
- silencing
- splicing
- aptamer
- gapmer
- siRNA
- CpG
- editing
- targeting
- delivery
- release
- analysis
- bioassay
- biosensor
- array
- disease
- diagnostics
- FISH
- beacons
- vaccine
- adjuvant
- immunomodulation
