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Molecular and Cellular Mechanisms of Pulmonary Toxicity and Lung Injury

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".

Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 1614

Special Issue Editors


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Guest Editor
1. Respiratory Medicine Department, Faculty of Medicine, University of Thessaly, Larissa, Greece
2. Respiratory Disorders Lab, Faculty of Nursing, University of Thessaly, Larissa, Greece
Interests: respiratory diseases; pulmonary embolism; interstitial lung diseases
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. Faculty of Medicine, University of Thessaly, Larissa, Greece
2. Center for Pediatrics and Adolescent Medicine, Heidelberg, Germany
Interests: mesothelial physiology; mesothelial pathophysiology; mesothelioma; tight junctions; adherens junctions; ion transport; water transport; biomarkers; serosal effusions; computational biology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The International Journal of Molecular Sciences has launched a Special Issue on “Molecular and Cellular Mechanisms of Pulmonary Toxicity and Lung Injury”.

Pulmonary Toxicity and Lung Injury is an umbrella term that encompasses acute or long-term lung damage due to a great variety of factors and chemical compounds. The most common causes of pulmonary toxicity include (but are not limited to) drugs, radiation exposure and asbestos. Specific patterns of lung injury may be seen with each agent although some overlap exists; for example, antineoplastic drugs may result in acute bronchoconstriction (e.g., carboplatin), alveolar hemorrhage (e.g., bevacizumab), eosinophilic pneumonia (e.g, lenalidomide) or hypersensitivity pneumonitis (e.g., bleomycin). The most common mechanisms involved in lung injury include cytotoxicity, oxidative injury and inflammation. However, the exact pathogenesis remains poorly understood.

We warmly invite you to submit your research to this Special Issue entitled “Molecular and Cellular Mechanisms of Pulmonary Toxicity and Lung Injury”.  We are calling for studies that address the pathophysiological and molecular issues that underline lung toxicity and injury. The research can include both in vitro and in vivo studies as well as animal models of disease. Additionally, we welcome literature reviews and systematic reviews.

Dr. Foteini Malli
Dr. Sotirios Zarogiannis
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pulmonary toxicity
  • lung injury
  • inflammation
  • cytotoxicity
  • oxidative injury
  • asbestos
  • bleomycin
  • methotrexate
  • antineoplastic drugs, radiation
  • pulmonary fibrosis

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Published Papers (1 paper)

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Research

16 pages, 3823 KiB  
Article
Transcriptional Changes in Radiation-Induced Lung Injury: A Comparative Analysis of Two Radiation Doses for Preclinical Research
by Mohamed El-Agamy Farh, Hyun-Jin Kim, Sang-Yeon Kim, Jae-Hee Lee, Hajeong Lee, Ronglan Cui, Soorim Han, Dong Wook Kim, Sunjoo Park, Yoon-Jin Lee, Yun-Sil Lee, Insuk Sohn and Jaeho Cho
Int. J. Mol. Sci. 2024, 25(7), 3766; https://doi.org/10.3390/ijms25073766 - 28 Mar 2024
Cited by 1 | Viewed by 1327
Abstract
In a recent stereotactic body radiation therapy animal model, radiation pneumonitis and radiation pulmonary fibrosis were observed at around 2 and 6 weeks, respectively. However, the molecular signature of this model remains unclear. This study aimed to examine the molecular characteristics at these [...] Read more.
In a recent stereotactic body radiation therapy animal model, radiation pneumonitis and radiation pulmonary fibrosis were observed at around 2 and 6 weeks, respectively. However, the molecular signature of this model remains unclear. This study aimed to examine the molecular characteristics at these two stages using RNA-seq analysis. Transcriptomic profiling revealed distinct transcriptional patterns for each stage. Inflammatory response and immune cell activation were involved in both stages. Cell cycle processes and response to type II interferons were observed during the inflammation stage. Extracellular matrix organization and immunoglobulin production were noted during the fibrosis stage. To investigate the impact of a 10 Gy difference on fibrosis progression, doses of 45, 55, and 65 Gy were tested. A dose of 65 Gy was selected and compared with 75 Gy. The 65 Gy dose induced inflammation and fibrosis as well as the 75 Gy dose, but with reduced lung damage, fewer inflammatory cells, and decreased collagen deposition, particularly during the inflammation stage. Transcriptomic analysis revealed significant overlap, but differences were observed and clarified in Gene Ontology and KEGG pathway analysis, potentially influenced by changes in interferon-gamma-mediated lipid metabolism. This suggests the suitability of 65 Gy for future preclinical basic and pharmaceutical research connected with radiation-induced lung injury. Full article
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