Tetraploid Cells in Health and Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 9037
Special Issue Editor
2. Laboratory of Molecular Biotechnology of Eukaryotes, Sfax Biotechnology Centre, Sfax University, Sfax, Tunisia
Interests: cell death; mitotic catastrophe; genomic instability; metastasis; migration; cancer
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Tetraploidization is the condition of having twice as many chromosomes as their normal, diploid counterparts. With the exception of some physiological statuses, cells do not tolerate the tetraploidy and activate programmed death pathways or elicit immune responses resulting in their elimination. However, tetraploidy can constitute a metastable intermediate between healthy diploidy and neoplastic aneuploidy. Indeed, tetraploid cells are detected in many cancers and are associated with cancer progression and aggressiveness, as well as therapeutic resistance and poor prognosis.
This Special Issue aims at presenting current status, recent developments, and future directions of research on tetraploid genomic status with emphasis on the following topics, but not only:
- Cancer research;
- Treatment therapy failure;
- Tetraploid stem cells;
- Animal models to study the disease mechanism of tetraploidization;
- Illicit survival of tetraploid cancer cells;
- Cancer metastasis provoked by tetraploidization.
Dr. Mohamed Jemaà
Guest Editor
Manuscript Submission Information
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Keywords
- polyploidy
- tetraploidy
- metastasis
- cancer
- polyploidazation
- therapy
- stem cells
- radiotherapy
- microtubules
- centrosomes
- mitotic chekpoints