Molecular Mechanisms of Uterine Receptivity for Embryo Implantation
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (15 December 2023) | Viewed by 11300
Special Issue Editor
Interests: human infertility; assisted reproduction; endocrinology; diagnosis; treatment; sperm quality; oocyte quality; embryo developmental potential
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
There is no doubt that contemporary diagnostic and treatment strategies aimed at resolving human infertility issues must be based on molecular medicine. Thus, the conventional schemes of diagnostic and therapeutic actions, which have been used for several decades, are to be abandoned in favour of patient-tailored interventions, considering the search for probable molecular issues hindering the establishment and further continuation of pregnancy until the birth of a healthy infant.
This approach revolves around a deep understanding of the molecular mechanisms involved in both embryo development and uterine function. In this Special Issue, we wish to analyse those issues related to uterine function that might cause implantation failure, miscarriage or late spontaneous abortion. Topics related to the molecular mechanisms of implantation, including the actions of the four major human chorionic gonadotropin (hCG) isoforms, classical hCG, hyperglycosylated hCH, free β subunit and sulphated hCG, in the essential events related to embryo implantation, including the function of the ovarian corpus luteum, restructuring of the endometrium, uterine angiogenesis, modification of the immune system and the prevention of early pregnancy loss, are of particular interest. Special attention should be paid to the ovarian–placental transition of progesterone production and possible effects of its alteration on pregnancy outcome. Both studies dealing with humans and those performed in relevant animal models will be considered.
Finally, new ideas about the choice of appropriate treatment methods adapted to specific molecular deficiencies of the female reproductive system are especially needed.
Dr. Jan Tesarik
Guest Editor
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Keywords
- uterine receptivity
- embryo implantation
- molecular control
- miscarriage prevention
- translational molecular medicine