Molecular Mechanisms and Pathophysiology of Cerebral Gliomas: Towards Development of New Treatments
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: closed (15 June 2024) | Viewed by 8184
Special Issue Editors
Interests: glioblastomas; intracellular signaling pathways; oxidative signaling; apoptosis; cell invasion; therapeutical approaches; tumoral microenvironment; preclinical models
Interests: glioblastomas; brain drug delivery; nanomedicine; preclinical model; drug repurposing; surgery; tumor microenvironment
Special Issues, Collections and Topics in MDPI journals
Interests: glioblastomas; cancer stem cells; tumor microenvironment; preclinical models; inhibitor of apoptosis; cell death; immune cells
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Gliomas are the most frequent brain tumors, and, irrespective of the advances in biological and pharmaceutical knowledge, they still represent an unmet medical need. Low-grade gliomas inexorably evolve to high-grade tumors. Grade IV gliomas, astrocytomas IDH-mutant and glioblastomas IDH-wild type are the most aggressive forms of tumor, which have a poor prognosis and few therapeutic solutions. The discovery of new biomarkers and new molecular mechanisms involved in gliomas pathophysiology is required to develop innovative and more effective treatments.
This Special Issue will include papers investigating the pathological mechanisms of gliomas and new druggable biomarkers. New therapeutic strategies and preclinical (in vitro, in vivo, ex vivo) studies are also welcome.
This Special Issue will gather original research articles and review papers. Potential topics include, but are not limited to, the following:
- Molecular mechanisms in gliomagenesis and tumor progression;
- Identification of new biomarkers;
- Crosstalk between tumor (stem) cells and the brain microenvironment;
- New preclinical models (in vitro, in vivo, ex vivo, patient’s derived models);
- Innovative therapeutic approaches.
Dr. Alessandra Pagano
Dr. Chiara Bastiancich
Dr. Aurélie Tchoghandjian
Guest Editors
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Keywords
- gliomas pathophysiology
- biomarkers
- microenvironment
- cancer stem cells
- brain resident cells
- omics approaches
- preclinical models
- targeted treatment
- brain drug delivery
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