The Impact and Alterations of Hormones in Age-Related Diseases and Comorbidities
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 31 October 2024 | Viewed by 85
Special Issue Editor
Interests: aging and comorbidities; hormone regulation and function; endocrine physiology and pathophysiology; signal transduction pathways; steroidogenesis; hormonal alterations in aging; tumorigenesis; genetics and epigenetics; immunomodulation; neurodegenerative processes; therapeutic strategies
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Aging is an inevitable heterogeneous phenomenon involving the whole organism and results in a deterioration in the central nervous system and the endocrine system. Multifaceted and complex changes, affecting the structural and functional efficacies of a multitude of organs, occur when life progresses from adulthood to senescence, and result in a decline of various hormones. The occurrence of hormone deficiencies is constituted to be the major cause of human senescence and it is associated with numerous health complications and comorbidities along with a host of pathologies. Needless to say, hormones influence nearly all physiological and pathophysiological processes, ranging from organogenesis to carcinogenesis to neurodegeneration, which involve the hypothalamic–pituitary–thyroid–adrenal–gonadal (HPTAG) auto regulating system. Age-related disruption of the HPTAG axis modulates the immune system and contribute to increased morbidity and mortality. The manifestations of these insufficiencies include, but are not limited to, diminished eyesight, impaired memory and cognitive function connecting neurodegenerative diseases, decreased muscle mass and bone density, decreased steroid biosynthesis, sexual dysfunction and depression, increased risk in cardiovascular diseases (CVDs), and various skin disorders and cancers. These conditions profoundly affect the elderly women and men within the context of a substantial rise in life expectancy, thus, preservation of bodily and hormonal homeostasis for proper functioning of diverse activities. Notably, age-related diverse complications and diseases are also impacted by immunocompromised conditions, including diabetes, obesity, CVDs, and cancers. A variety of hormones play pivotal roles in many, if not all, of these above-mentioned situations. Therefore, the improvement of physical function and mobility, in reinstating bodily/hormonal homeostasis, in continuously growing aging populations is a high priority of medicine today for healthy living of geriatric populations.
This Special Issue is aimed to publish original research and review articles that address current knowledge and understanding of fundamental, cellular, and molecular events involved in age-associated vulnerabilities, correlation to hormonal disparities, and potential therapeutic interventions.
Dr. Pulak R. Manna
Guest Editor
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Keywords
- aging
- age-related complications
- comorbidities
- aging and hormones
- immunosenescence
- impact of hormones in physiology and pathophysiology
- immunocompromised conditions
- neurodegenerative disorders
- bodily homeostasis
- healthy aging
