Hormone-Sensitve Cancers: Pathogenesis and Therapeutics
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (20 October 2024) | Viewed by 7537
Special Issue Editor
Interests: aging and comorbidities; hormone regulation and function; endocrine physiology and pathophysiology; signal transduction pathways; steroidogenesis; hormonal alterations in aging; tumorigenesis; genetics and epigenetics; immunomodulation; neurodegenerative processes; therapeutic strategies
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Hormone-sensitive cancers are influenced by a variety of events, including hormonal, genetic, and environmental factors. Specifically, dysregulation of the steroidogenic machinery, involving sex steroid hormones, has long been linked to the pathogenesis of a variety of hormone-sensitive malignancies, including breast, prostrate, and gynecological cancers. Despite recent advances in genetic and proteomic landscapes detailing regulatory insights into various relevant cancers, mortality rates remain very high globally. An early diagnosis of any of these cancers can significantly reduce morbidity and psychological distress, and possibly even save the life in certain cases, in patients afflicted with the indicated aggressive malignant diseases. In-depth understanding of tumor microenvironment, heterogeneity and signaling pathways, utilizing/analyzing pertinent cell lines, primary tumors, and bioinformatics, along with genomic and molecular profiles, would be valuable for establishing novel biomarker(s) revealing diagnosis and staging of different cancer types. While considerable challenges exist for development of a therapeutic target for the specific cancer type mentioned, accumulating evidence indicates that histone deacetylase (HDAC) inhibitors, by targeting multiple aspects, display favorable outcomes in a number of these hormone-dependent cancers, since dysregulation of HDACs is primary event in tumorigenesis. Under these circumstances, discovery of novel agents effective for diagnostic, preventive, and therapeutic purposes should be the major focus for combating various hormone-sensitive cancers.
This Special Issue provides a venue for publishing both original research and review articles that enhance improved understanding of therapeutic strategies facilitating diagnosis and treatment for any hormone-dependent cancer.
Dr. Pulak R. Manna
Guest Editor
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Keywords
- hormone-sensitive cancers
- hormone dysregulation
- steroid hormones
- mechanistic insights
- signaling crosstalk
- oncogenic events
- epigenetics
- tumor suppressor genes
- bioinformatics
- endocrine pathophysiology
- signaling pathways
- anticancer agents
- therapeutic strategies
- aging and cancers
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