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Steroids and Neuropsychiatric Disorders

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 590

Special Issue Editor


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Guest Editor
Department of Steroids and Proteofactors, Institute of Endocrinology, Národní 8, 116 94 Prague, Czech Republic
Interests: steroids; steroidomics; chemometrics; neuroactive steroids; steroids and pregnancy; chromatography
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Already more than 80 years ago, Selye described the rapid neuroinhibitory effect of allopregnanolone. Since then, many articles have been published on the role of bioactive steroids in the pathophysiology of neuropsychiatric diseases. Nevertheless, there remains a vast scope to study the relationship between steroids and these pathologies regarding steroid biosynthesis and metabolism, including steroid effects and the diagnosis of these diseases based on steroidomic changes. Therefore, this special edition aims to gain further insights and expand the existing horizon. We welcome both original and review papers focusing on the relationship between steroids and epilepsy, Alzheimer’s disease, multiple sclerosis, Parkinson’s disease, schizophrenia, panic disorder, bipolar disorder, anxiety, attention deficit disorder, autism, premenstrual syndrome, peripartum depression and anxiety, hyperactivity disorder, personality disorder, sleep disorders, etc., in terms of their effects, the steroidomic changes accompanying these diseases and the effects of psychotropic drugs on the steroidome.

Dr. Martin Hill
Guest Editor

Manuscript Submission Information

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Keywords

  • neuropsychiatric disorders
  • steroid hormones
  • neuroactive steroids
  • immunoactive steroids
  • steroidomics
  • pathophysiology
  • effects of psychotropic drugs on steroidome
  • siagnosis

Published Papers (1 paper)

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Research

28 pages, 1032 KiB  
Article
Association between Disgust Sensitivity during Pregnancy and Endogenous Steroids: A Longitudinal Study
by Šárka Kaňková, Daniela Dlouhá, Jana Ullmann, Marta Velíková, Josef Včelák and Martin Hill
Int. J. Mol. Sci. 2024, 25(13), 6857; https://doi.org/10.3390/ijms25136857 - 22 Jun 2024
Cited by 1 | Viewed by 418
Abstract
The emotion of disgust protects individuals against pathogens, and it has been found to be elevated during pregnancy. Physiological mechanisms discussed in relation to these changes include immune markers and progesterone levels. This study aimed to assess the association between steroids and disgust [...] Read more.
The emotion of disgust protects individuals against pathogens, and it has been found to be elevated during pregnancy. Physiological mechanisms discussed in relation to these changes include immune markers and progesterone levels. This study aimed to assess the association between steroids and disgust sensitivity in pregnancy. Using a prospective longitudinal design, we analyzed blood serum steroid concentrations and measured disgust sensitivity via text-based questionnaires in a sample of 179 pregnant women during their first and third trimesters. We found positive correlations between disgust sensitivity and the levels of C19 steroids (including testosterone) and its precursors in the Δ5 pathway (androstenediol, DHEA, and their sulfates) and the Δ4 pathway (androstenedione). Additionally, positive correlations were observed with 5α/β-reduced C19 steroid metabolites in both trimesters. In the first trimester, disgust sensitivity was positively associated with 17-hydroxypregnanolone and with some estrogens. In the third trimester, positive associations were observed with cortisol and immunoprotective Δ5 C19 7α/β-hydroxy-steroids. Our findings show that disgust sensitivity is positively correlated with immunomodulatory steroids, and in the third trimester, with steroids which may be related to potential maternal-anxiety-related symptoms. This study highlights the complex relationship between hormonal changes and disgust sensitivity during pregnancy. Full article
(This article belongs to the Special Issue Steroids and Neuropsychiatric Disorders)
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