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Novel Molecular Mechanisms Underlying Tumorigenesis and Innovative Therapeutic Approaches for Cancer-Fighting, 3rd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 31 October 2024 | Viewed by 528

Special Issue Editors

Special Issue Information

Dear Colleagues,

According to the World Health Organization, cancer is the most common cause of premature death in developed countries. Conventional cancer treatment involves the therapeutic application of chemotherapeutic agents associated with surgical therapy. However, the clinical outcome of this therapeutic approach can be unsatisfactory, especially in patients with advanced disease. Furthermore, common chemotherapeutic drugs show high levels of toxicity for normal cells, which is often associated with the development of chemoresistance. For these reasons, oncological research has focused on finding innovative therapies that increase the specificity of the treatment and reduce their drawbacks. New therapeutic approaches for cancer treatment, currently under evaluation in many clinical trials worldwide, include but are not limited to molecules targeting the nucleolus, natural antioxidants and phytochemicals in combination with common chemotherapeutic drugs, expression of genes triggering apoptosis, tumor suppressors, targeted silencing mediated by siRNAs, and the nanodelivery of chemotherapeutics.

The combination of new and conventional approaches allows oncologists to select the best and most personalized therapy for cancer treatment.

This Special Issue, led by Dr. Giulia Russo and Dr. Annapina Russo with the assistance of our Topical Advisory Panel Members and the GE’s assistant editor Dr. Annalisa Pecoraro (Department of Pharmacy, University of Naples Federico II, 80131 Napoli, Italy), will document studies on the molecular mechanism underlying tumorigenesis and on innovative strategies for cancer treatment.

More published papers could be found in the closed Special Issues: Novel Molecular Mechanisms Underlying Tumorigenesis and Innovative Therapeutic Approaches for Cancer-Fighting and Novel Molecular Mechanisms Underlying Tumorigenesis and Innovative Therapeutic Approaches for Cancer-Fighting 2.0.

Dr. Annapina Russo
Dr. Giulia Russo
Guest Editors

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Keywords

  • cancer
  • nucleolus
  • nucleolar stress
  • tumorigenesis
  • cancer therapy

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Published Papers (1 paper)

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Research

14 pages, 15074 KiB  
Article
The Vasopressin Receptor Antagonist Tolvaptan Counteracts Tumor Growth in a Murine Xenograft Model of Small Cell Lung Cancer
by Laura Naldi, Benedetta Fibbi, Simone Polvani, Chiara Cirillo, Francesca Pasella, Francesca Bartolini, Francesca Romano, Alessandra Fanelli, Alessandro Peri and Giada Marroncini
Int. J. Mol. Sci. 2024, 25(15), 8402; https://doi.org/10.3390/ijms25158402 - 1 Aug 2024
Viewed by 390
Abstract
We have previously demonstrated that the vasopressin type 2 receptor (AVPR2) antagonist tolvaptan reduces cell proliferation and invasion and triggers apoptosis in different human cancer cell lines. To study this effect in vivo, a xenograft model of small cell lung cancer was developed [...] Read more.
We have previously demonstrated that the vasopressin type 2 receptor (AVPR2) antagonist tolvaptan reduces cell proliferation and invasion and triggers apoptosis in different human cancer cell lines. To study this effect in vivo, a xenograft model of small cell lung cancer was developed in Fox1nu/nu nude mice through the subcutaneous inoculation of H69 cells, which express AVPR2. One group of mice (n = 5) was treated with tolvaptan for 60 days, whereas one group (n = 5) served as the control. A reduced growth was observed in the tolvaptan group in which the mean tumor volume was significantly smaller on day 60 compared to the control group. In the latter group, a significantly lower survival was observed. The analysis of excised tumors revealed that tolvaptan effectively inhibited the cAMP/PKA and PI3K/AKT signaling pathways. The expression of the proliferative marker proliferating cell nuclear antigen (PCNA) was significantly lower in tumors excised from tolvaptan-treated mice, whereas the expression levels of the apoptotic marker caspase-3 were higher than those in control animals. Furthermore, tumor vascularization was significantly lower in the tolvaptan group. Overall, these findings suggest that tolvaptan counteracts tumor progression in vivo and, if confirmed, might indicate a possible role of this molecule as an adjuvant in anticancer strategies. Full article
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