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New Advances in Stem Cells in Human Health and Diseases
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New Advances in Stem Cells in Human Health and Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 20 March 2025 | Viewed by 1992

Special Issue Editor

Dr. Elisaveta N. Voynova

E-Mail Website
Guest Editor
Clinical Research Correlatives Core, National Cancer Institute, National Health Institute, Bethesda, MD, USA
Interests: cell therapy; hematopoietic stem cell; cancer; cancer immunotherapy

Special Issue Information

Dear Colleagues,

Stem cells are unspecialized cells of the human body. They can be induced to differentiate into many cell types and have the ability to self-renew. They are able to go through numerous cycles of cell division and capacity to develop into any cell type. Stem cells have the ability to repair damaged or destroyed tissues; thus, they have great potential to become one of the most important aspects of medicine. Stem cell therapy can be implemented in the treatment of a variety of diseases and conditions like neurodegenerative diseases, fertility, transplantation, arthroplasty, and many others.

Despite great treatment potential, there are still many obstacles to overcome: improving the efficiency of stem-cell-directed differentiation, understanding the mechanisms by which stem cells function, discovering the ability to produce fully functional organs made by stem cells, and preventing immunological rejection, which is a major barrier to successful stem cell transplantation.

The main aim of this Special Issue is to cover recent significant advances in basic stem cell research that could translate and improve potential stem cell therapies in the future.

Dr. Elisaveta N. Voynova
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • stem cells biology
  • iPSCs
  • hESC

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Published Papers (2 papers)

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Research

14 pages, 2510 KiB  
Article
Non-Cytotoxic Graphene Nanoplatelets Upregulate Cell Proliferation and Self-Renewal Genes of Mesenchymal Stem Cells
by Natália Fontana Nicoletti, Daniel Rodrigo Marinowic, Daniele Perondi, João Ismael Budelon Gonçalves, Diego Piazza, Jaderson Costa da Costa and Asdrubal Falavigna
Int. J. Mol. Sci. 2024, 25(18), 9817; https://doi.org/10.3390/ijms25189817 - 11 Sep 2024
Viewed by 631
Abstract
Graphene nanoplatelets (UGZ–1004) are emerging as a promising biomaterial in regenerative medicine. This study comprehensively evaluates UGZ–1004, focusing on its physical properties, cytotoxicity, intracellular interactions, and, notably, its effects on mesenchymal stem cells (MSCs). UGZ–1004 was characterized by lateral dimensions and layer counts [...] Read more.
Graphene nanoplatelets (UGZ–1004) are emerging as a promising biomaterial in regenerative medicine. This study comprehensively evaluates UGZ–1004, focusing on its physical properties, cytotoxicity, intracellular interactions, and, notably, its effects on mesenchymal stem cells (MSCs). UGZ–1004 was characterized by lateral dimensions and layer counts consistent with ISO standards and demonstrated a high carbon purity of 0.08%. Cytotoxicity assessments revealed that UGZ–1004 is non-toxic to various cell lines, including 3T3 fibroblasts, VERO kidney epithelial cells, BV–2 microglia, and MSCs, in accordance with ISO 10993–5:2020/2023 guidelines. The study focused on MSCs and revealed that UGZ–1004 supports their gene expression alterations related to self-renewal and proliferation. MSCs exposed to UGZ–1004 maintained their characteristic surface markers. Importantly, UGZ–1004 promoted significant upregulation of genes crucial for cell cycle regulation and DNA repair, such as CDK1, CDK2, and MDM2. This gene expression profile suggests that UGZ–1004 can enhance MSC self-renewal capabilities, ensuring robust cellular function and longevity. Moreover, UGZ–1004 exposure led to the downregulation of genes associated with tumor development, including CCND1 and TFDP1, mitigating potential tumorigenic risks. These findings underscore the potential of UGZ–1004 to not only bolster MSC proliferation but also enhance their self-renewal processes, which are critical for effective regenerative therapies. The study highlights the need for continued research into the long-term impacts of graphene nanoplatelets and their application in MSC-based regenerative medicine. Full article
(This article belongs to the Special Issue New Advances in Stem Cells in Human Health and Diseases)
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11 pages, 2363 KiB  
Article
Impact of Inflammatory Markers and Senescence-Associated Secretory Phenotype in the Gingival Crevicular Fluid on the Outcomes of Periodontal Regeneration
by Giacomo Baima, Federica Romano, Francesco Franco, Ilaria Roato, Federico Mussano, Giovanni Nicolao Berta and Mario Aimetti
Int. J. Mol. Sci. 2024, 25(12), 6687; https://doi.org/10.3390/ijms25126687 - 18 Jun 2024
Viewed by 683
Abstract
The aim of this study was to test the molecular expression profile (senescence-associated secretory phenotype; SASP) in gingival crevicular fluid (GCF) prior to surgery in relation to the distribution of clinical success of periodontal regeneration. Forty consecutive patients presenting sites with residual probing [...] Read more.
The aim of this study was to test the molecular expression profile (senescence-associated secretory phenotype; SASP) in gingival crevicular fluid (GCF) prior to surgery in relation to the distribution of clinical success of periodontal regeneration. Forty consecutive patients presenting sites with residual probing pocket depth (PPD) ≥ 6 mm and intrabony defects ≥ 3 mm were treated through a minimally invasive surgical technique. Pre-operatively, GCF was sampled for inflammatory biomarker analysis related to SASP [interleukin (IL)-1β, IL-6, and IL-12; matrix-metalloproteinases (MMP)-8 and -9]. Better or worse responders were classified depending on the achievement of a composite outcome measure at 1-year [COM; PPD ≤ 4 mm and clinical attachment gain (CAL) gain ≥ 3 mm]. Correlation analyses and logistic regression models were performed. Periodontal regeneration led to significant improvements in mean clinical and radiographic parameters. Teeth achieving COM presented significantly lower amounts of SASP factors compared with non-successful teeth. Higher CAL gain, PPD reduction, and radiographic bone fill were negatively correlated with IL-1β and MMP-8 and -9 (p < 0.001), while IL-12 showed a direct relationship with CAL gain (p = 0.005) and PPD reduction (p = 0.038). Sites expressing higher SASP expression in the GCF before periodontal regeneration achieved worse clinical and radiographic outcomes. Full article
(This article belongs to the Special Issue New Advances in Stem Cells in Human Health and Diseases)
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