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Molecular Insights into Multiple Sclerosis

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 714

Special Issue Editor


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Guest Editor
Department of Anatomy, Akita University Graduate School of Medicine, Hondo 1-1-1, Akita 010-8543, Japan
Interests: molecular pathology of multiple sclerosis

Special Issue Information

Dear Colleagues,

This Special Issue, "Molecular Insights into Multiple Sclerosis", delves into the intricate molecular mechanisms underlying the pathogenesis, progression, and potential therapeutic avenues for Multiple Sclerosis (MS). Leading researchers and experts contribute comprehensive reviews and original research articles, unraveling the intricate interplay of genetic, environmental, and immunological factors contributing to MS. Insights into novel biomarkers, emerging therapeutic targets, and cutting-edge technologies shaping MS research are highlighted, fostering a deeper understanding of this complex neurological disorder. This collection serves as a valuable resource for clinicians, scientists, and healthcare professionals engaged in MS research, offering a holistic perspective on the latest advancements and future directions in the field.

Prof. Dr. Yoshio Bando
Guest Editor

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Keywords

  • multiple sclerosis
  • molecular mechanism
  • pathogenesis
  • biomarkers
  • therapeutic targets

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Published Papers (1 paper)

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Research

15 pages, 263 KiB  
Article
CXCL12 Gene Polymorphisms and Serum Levels: Associations with Multiple Sclerosis Prevalence and Clinical Parameters in Lithuania
by Paulius Valiukevicius, Kriste Kaikaryte, Greta Gedvilaite-Vaicechauskiene, Renata Balnyte and Rasa Liutkeviciene
Int. J. Mol. Sci. 2024, 25(17), 9554; https://doi.org/10.3390/ijms25179554 - 3 Sep 2024
Viewed by 440
Abstract
Our study aimed to investigate the associations between CXCL12 rs1029153, rs1801157, and rs2297630 single-nucleotide polymorphisms (SNPs), CXCL12 protein levels, MS prevalence, and clinical parameters. This study included 250 individuals diagnosed with MS and 250 sex- and age-matched healthy control individuals from Lithuania. The [...] Read more.
Our study aimed to investigate the associations between CXCL12 rs1029153, rs1801157, and rs2297630 single-nucleotide polymorphisms (SNPs), CXCL12 protein levels, MS prevalence, and clinical parameters. This study included 250 individuals diagnosed with MS and 250 sex- and age-matched healthy control individuals from Lithuania. The SNPs were genotyped with real-time PCR-based assays. The CXCL12 protein concentration was evaluated in serum using the ELISA method. Of the studied CXCL12 SNPs, we found that the rs1801157 CT genotype in the males was associated with 2.3 times reduced MS odds when compared with the CC genotype according to the overdominant and codominant models (p = 0.011 and p = 0.012, respectively). There was a tendency, which did not reach adjusted statistical significance, for a lower CXCL12 protein concentration in the healthy individuals with the rs1801157 CT genotype (p = 0.028). Sensory symptoms were rarer in the women with the rs1801157 TT genotype (p = 0.004); however, this genotype was also associated with a shorter MS disease duration (p = 0.007). CXCL12 rs1801157 was associated with reduced odds of MS occurrence in the male individuals. In women, rs1801157 was associated with a sensory symptom prevalence. Full article
(This article belongs to the Special Issue Molecular Insights into Multiple Sclerosis)
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