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Molecular Mechanisms of Allergy and Skin Diseases
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Molecular Mechanisms of Allergy and Skin Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: closed (30 December 2022) | Viewed by 9501

Special Issue Editors

Dr. Hideo Hashizume

E-Mail Website
Guest Editor
Department of Dermatology, Shimada Municipal Hospital, Shizuoka, Japan
Interests: dermatology; allergy; anaphylaxis; immunology; drug hypersensitivity
Special Issues, Collections and Topics in MDPI journals
Dr. Taisuke Ito

E-Mail Website
Guest Editor
Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan
Interests: skin; T lymphocytes; dermatology; immunity
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Skin resides the boundaries between outer and inside of the body, repelling invaders immunologically and retaining water for keeping important functional biochemicals. Breaking down the mechanistic functions may cause various skin diseases. Easy access to skin allows to take efficient skin sample specimens and conduct extensive research on skin microenvironment under physiological and pathogenic conditions. Recent mainstay of therapeutic strategy is targeting critical biological molecules in chronic skin inflammatory disorders such as atopic dermatitis and psoriasis. This not only brings remarkable effects on them but also reveals novel functions and cryptic roles of such molecules. Comprehensive genome analysis disclosed a novel pathogenic gene and its critical role of the pathogenesis of autoinflammatory skin disorders. New computer technology of analysing conformational relationships between HLA and drugs has revealed novel mechanisms of the pathogenesis of drug hypersensitivity. We have learned much from excellent studies on skin diseases and clinical experience of novel treatments, inspiring many researchers as a pioneer in medical science.

This issue of the International Journal of Molecular Sciences will focus on “Molecular Mechanisms of Allergy and Skin Diseases”, including new insight into the pathogenesis and treatment of immune-mediated skin disorders. New data on allergy and immune-mediated skin diseases are welcome.

Dr. Hideo Hashizume
Dr. Taisuke Ito
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • allergy
  • drug hypersensitivity
  • atopic dermatitis
  • psoriasis

Published Papers (3 papers)

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Research

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14 pages, 4156 KiB  
Article
The Allergenic Activity of Blo t 2, a Blomia tropicalis IgE-Binding Molecule
by Ernesto Mondol, Karen Donado, Ronald Regino, Karen Hernandez, Dilia Mercado, Ana Carolina Mercado, Inés Benedetti, Leonardo Puerta, Josefina Zakzuk and Luis Caraballo
Int. J. Mol. Sci. 2023, 24(6), 5543; https://doi.org/10.3390/ijms24065543 - 14 Mar 2023
Cited by 3 | Viewed by 1666
Abstract
Only few allergens derived from house dust mite (HDM) species have been evaluated in terms of their potential to induce allergic inflammation. In this study, we aimed to evaluate different aspects of the allergenicity and allergenic activity of Blo t 2, a Blomia [...] Read more.
Only few allergens derived from house dust mite (HDM) species have been evaluated in terms of their potential to induce allergic inflammation. In this study, we aimed to evaluate different aspects of the allergenicity and allergenic activity of Blo t 2, a Blomia tropicalis allergen. Blo t 2 was produced as a recombinant protein in Escherichia coli. Its allergenic activity was tested in humans by skin prick test and basophil activation assays, and in mice, by passive cutaneous anaphylaxis and a model of allergic airway inflammation. Sensitization rate to Blo t 2 (54.3%) was similar to that found to Blo t 21 (57.2%) and higher than to Der p 2 (37.5%). Most Blo t 2-sensitized patients showed a low intensity response (99.5%). Blo t 2 elicited CD203c upregulation and allergen induced skin inflammation. Additionally, immunized animals produced anti-Blo t 2 IgE antibodies and passive transfer of their serum to non-immunized animals induced skin inflammation after allergen exposure. Immunized animals developed bronchial hyperreactivity and a strong inflammatory lung reaction (eosinophils and neutrophils). These results confirm the allergenic activity of Blo t 2 and supports its clinical relevance. Full article
(This article belongs to the Special Issue Molecular Mechanisms of Allergy and Skin Diseases)
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19 pages, 2317 KiB  
Article
Structural and Immunologic Properties of the Major Soybean Allergen Gly m 4 Causing Anaphylaxis
by Ekaterina I. Finkina, Ivan V. Bogdanov, Rustam H. Ziganshin, Nikita N. Strokach, Daria N. Melnikova, Ilia Y. Toropygin, Natalia S. Matveevskaya and Tatiana V. Ovchinnikova
Int. J. Mol. Sci. 2022, 23(23), 15386; https://doi.org/10.3390/ijms232315386 - 6 Dec 2022
Cited by 2 | Viewed by 1673
Abstract
Gly m 4 is the major soybean allergen, causing birch pollen cross allergic reactions. In some cases, Gly m 4-mediated anaphylaxis takes place, but the causative factors are still unknown. Here, we studied the structural and immunologic properties of Gly m 4 to [...] Read more.
Gly m 4 is the major soybean allergen, causing birch pollen cross allergic reactions. In some cases, Gly m 4-mediated anaphylaxis takes place, but the causative factors are still unknown. Here, we studied the structural and immunologic properties of Gly m 4 to shed light on this phenomenon. We showed that Gly m 4 retained its structure and IgE-binding capacity after heating. Gly m 4 was cleaved slowly under nonoptimal gastric conditions mimicking duodenal digestion, and IgE from the sera of allergic patients interacted with the intact allergen rather than with its proteolytic fragments. Similar peptide clusters of Bet v 1 and Gly m 4 were formed during allergen endolysosomal degradation in vitro, but their sequence identity was insignificant. Animal polyclonal anti-Gly m 4 and anti-Bet v 1 IgG weakly cross-reacted with Bet v 1 and Gly m 4, respectively. Thus, we supposed that not only conserved epitopes elicited cross-reactivity with Bet v 1, but also variable epitopes were present in the Gly m 4 structure. Our data suggests that consumption of moderately processed soybean-based drinks may lead to the neutralizing of gastric pH as a result of which intact Gly m 4 can reach the human intestine and cause IgE-mediated system allergic reactions. Full article
(This article belongs to the Special Issue Molecular Mechanisms of Allergy and Skin Diseases)
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Review

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27 pages, 1905 KiB  
Review
Critical Players and Therapeutic Targets in Chronic Itch
by Hua Yang, Weiwei Chen, Renkai Zhu, Jiafu Wang and Jianghui Meng
Int. J. Mol. Sci. 2022, 23(17), 9935; https://doi.org/10.3390/ijms23179935 - 1 Sep 2022
Cited by 14 | Viewed by 5604
Abstract
Chronic itch is one of the most prominent clinical characteristics of diverse systematic diseases. It is a devastating sensation in pathological diseases. Despite its importance, there are no FDA-labelled drugs specifically geared toward chronic itch. The associated complex pathogenesis and diverse causes escalate [...] Read more.
Chronic itch is one of the most prominent clinical characteristics of diverse systematic diseases. It is a devastating sensation in pathological diseases. Despite its importance, there are no FDA-labelled drugs specifically geared toward chronic itch. The associated complex pathogenesis and diverse causes escalate chronic itch to being one of the top challenges in healthcare. Humanized antibodies against IL-13, IL-4, and IL-31 proved effective in treatment of itch-associated atopic dermatitis but remain to be validated in chronic itch. There are still no satisfactory anti-itch therapeutics available toward itch-related neuropeptides including GRP, BNP, SST, CGRP, and SP. The newly identified potential itch targets including OSM, NMB, glutamate, periostin, and Serpin E1 have opened new avenues for therapeutic development. Proof-of-principle studies have been successfully performed on antagonists against these proteins and their receptors in itch treatment in animal models. Their translational interventions in humans need to be evaluated. It is of great importance to summarize and compare the newly emerging knowledge on chronic itch and its pathways to promote the development of novel anti-itch therapeutics. The goal of this review is to analyze the different physiologies and pathophysiologies of itch mediators, whilst assessing their suitability as new targets and discussing future therapeutic development. Full article
(This article belongs to the Special Issue Molecular Mechanisms of Allergy and Skin Diseases)
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