Molecular Research in Antidepressant Response
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (15 November 2022) | Viewed by 5387
Special Issue Editors
2. Leibniz Institute for Resilience Research, 55131 Mainz, Germany
Interests: depression; animal model; translational psychiatry; antidepressants; resilience; stress
2. Laboratory of Translational Psychiatry, Dept. of Psychiatry and Psychotherapy and Focus Program Translational Neurosciences, Johannes Gutenberg University Medical Center Mainz, 55128 Mainz, Germany
Interests: depression; translational psychiatry; precision psychiatry; antidepressants; systems biology; treatment response
Special Issue Information
Dear Colleagues,
Treating depression is not a one-size-fits-all approach. Although it would be ideal to better target available treatments to individual patients, there are no useful assessments that can predict with a reasonable high degree of certainty—a priori or early in treatment—whether a particular depressed patient will respond to a particular antidepressant.
To tackle this challenge, animal-based approaches offer the unique advantage of allowing unrestricted access to the brain and making use of the unparalleled methodological toolbox for causal manipulation. Nevertheless, studies in patients to generate hypotheses for proof-of-concept and validation of findings are an indispensable step if we are to achieve a fundamental, mechanistic understanding of the phenomenon of “response”. Moreover, the enormous importance of factors and mechanisms outside the CNS—in terms of a systems biology understanding of depression and its successful therapy—is becoming increasingly recognized. This in turn opens up entirely new perspectives on the pathophysiology of depressive disorders and their highly prevalent somatic comorbidities such as cardiovascular and metabolic diseases and offers the prospect of conceptually novel therapeutic approaches.
With this Special Issue, we aim to advance the field by providing insights into refined animal models, improved behavioral readouts, and translationally relevant endophenotypes which can reliably inform us about the neurobiological and molecular mechanisms of antidepressant response in the animal. Moreover, we will address the phenomenon of response to antidepressant therapy from a systems biology perspective and highlight new areas of research aiming to decode the underlying molecular and systems biology (e.g., gender-related, nutritional and metabolic, inflammatory and immune) processes.
Prof. Dr. Marianne B. Müller
Dr. Jan Engelmann
Guest Editors
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Keywords
- antidepressant response
- antidepressant signatures
- major depressive disorder
- animal model
- molecular mechanism
- systems biology
- antidepressant biomarkers
- depression phenotype
- antidepressant drugs
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