Bone Metastasis: Pathophysiology and Molecular Mechanisms
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 September 2018) | Viewed by 64358
Special Issue Editor
Interests: breast cancer; bone metastases; microenvironment; bone microvasculature; tumour cell dormancy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Bone metastases, common features of advanced breast and prostate cancer, are increasingly also found in patients with other cancers (e.g., lung) due to improved treatment of the primary tumour and, hence, prolonged survival. However, once skeletal involvement is established, patient survival is limited and treatment often limited to palliation. The main current therapies are bone-targeted agents to prevent and/or reduce skeletal related events like fractures and spinal cord compression. However, no treatment specifically prevents the development of bone metastases. Novel therapeutic approaches to improve outcome for these poor prognosis patients require a better understanding of the molecular and cellular mechanisms that underpin tumour cell dissemination, colonisation and progression in bone. In particular, the role of the bone microenvironment in regulation of cancer cell dormancy, as well as identification of the signals that trigger escape from dormancy, remain to be elucidated. Another main area of interest is how tumour cell interactions with the bone microenvironment represents novel therapeutic targets, in particular in relation to new treatment modalities like immunotherapy.
This Special Issue will contain a collection of manuscripts that describe investigations into the different stages of bone metastasis, covering a range of model systems and tumour types, reflecting our current knowledge.
Prof. Dr. Ingunn Holen
Guest Editors
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Keywords
- bone
- bone microenvironment
- bone metastases
- breast cancer
- disseminated tumour cells
- extracellular matrix
- lung cancer
- prostate cancer
- tumour cell dormancy
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