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Dietary Bioactive Compounds and Breast Cancer II
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Dietary Bioactive Compounds and Breast Cancer II

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 24929

Special Issue Editors

Dr. Antonio González-Sarrías

E-Mail Website
Guest Editor
Laboratory of Food and Health, Food and Technology Department, National Council for Scientific Research (CEBAS-CSIC), Murcia, Spain
Interests: food and health; bioactive compounds; polyphenols; cell culture and animal models; clinical trials; cardiovascular; cancer; inflammation
Special Issues, Collections and Topics in MDPI journals
Dr. Juan Antonio Giménez-Bastida

E-Mail Website
Guest Editor
Laboratory of Food and Helath, Research Group on Quality, Safety and Bioactivity of Plant Foods, Department Food Science and Technology, CEBAS-CSIC, P.O. Box 164, Campus de Espinardo, 30100 Murcia, Spain
Interests: polyphenols; in vitro; in vivo; pharmacology; eicosanoids; inflammation; cardiovascular; health; bioactive molecules
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Breast cancer is the most common cancer and one of the leading causes of cancer-related death in women worldwide. Over 80% of cases are non-hereditary; therefore, modifiable extrinsic factors related to lifestyle, including dietary habits, play a key role in its prevention. Plant foodstuffs are the most important source of bioactive compounds, including polyphenols, carotenoids, and phytosterols, which have been reported to exert anticancer effects through exerting a broad range of pleiotropic multi-targeted effects on breast cancer cells in animal models. Although many epidemiological and observational studies have inversely correlated the consumption of fruits and vegetables with the incidence of breast cancer, the involvement of their phytochemicals remains still unclear. Over the past few decades, approaches that have not considered the bioavailability and metabolism of these compounds have been behind the current gap between preclinical and clinical research.

Therefore, this Special Issue of International Journal of Molecular Sciences will publish original research and review papers on the chemopreventive and/or chemosensitization effects of dietary bioactive compounds and/or derived metabolites on breast cancer using physiologically relevant preclinical (cell and animal models) and clinical approaches, which could elucidate if they are responsible for the effects attributed to plant-based foods.

Importantly, the exact active ingredient of natural origin extract must be reported in the submitted research manuscript, since papers describing the effects of mixed extraction from natural origin are not in the scope of the journal.

Dr. Antonio González-Sarrías
Dr. Juan Antonio Giménez-Bastida
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • breast cancer
  • chemoprevention
  • plant foods
  • phytochemicals
  • phytoestrogens
  • polyphenols
  • bioavailability studies
  • clinical trials
  • animal and cellular studies
  • anti-cancer mechanisms

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Published Papers (3 papers)

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Research

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16 pages, 2040 KiB  
Article
Milk-Derived Exosomes as Nanocarriers to Deliver Curcumin and Resveratrol in Breast Tissue and Enhance Their Anticancer Activity
by Antonio González-Sarrías, Carlos E. Iglesias-Aguirre, Adrián Cortés-Martín, Fernando Vallejo, Alice Cattivelli, Lorena del Pozo-Acebo, Andrea Del Saz, María Carmen López de las Hazas, Alberto Dávalos and Juan Carlos Espín
Int. J. Mol. Sci. 2022, 23(5), 2860; https://doi.org/10.3390/ijms23052860 - 5 Mar 2022
Cited by 62 | Viewed by 6611
Abstract
Dietary (poly)phenols are extensively metabolized, limiting their anticancer activity. Exosomes (EXOs) are extracellular vesicles that could protect polyphenols from metabolism. Our objective was to compare the delivery to breast tissue and anticancer activity in breast cancer cell lines of free curcumin (CUR) and [...] Read more.
Dietary (poly)phenols are extensively metabolized, limiting their anticancer activity. Exosomes (EXOs) are extracellular vesicles that could protect polyphenols from metabolism. Our objective was to compare the delivery to breast tissue and anticancer activity in breast cancer cell lines of free curcumin (CUR) and resveratrol (RSV) vs. their encapsulation in milk-derived EXOs (EXO-CUR and EXO-RSV). A kinetic breast tissue disposition was performed in rats. CUR and RSV were analyzed using UPLC-QTOF-MS and GC-MS, respectively. Antiproliferative activity was tested in MCF-7 and MDA-MB-231 breast cancer and MCF-10A non-tumorigenic cells. Cell cycle distribution, apoptosis, caspases activation, and endocytosis pathways were determined. CUR and RSV peaked in the mammary tissue (41 ± 15 and 300 ± 80 nM, respectively) 6 min after intravenous administration of EXO-CUR and EXO-RSV, but not with equivalent free polyphenol concentrations. Nanomolar EXO-CUR or EXO-RSV concentrations, but not free CUR or RSV, exerted a potent antiproliferative effect on cancer cells with no effect on normal cells. Significant (p < 0.05) cell cycle alteration and pro-apoptotic activity (via the mitochondrial pathway) were observed. EXO-CUR and EXO-RSV entered the cells primarily via clathrin-mediated endocytosis, avoiding ATP-binding cassette transporters (ABC). Milk EXOs protected CUR and RSV from metabolism and delivered both polyphenols to the mammary tissue at concentrations compatible with the fast and potent anticancer effects exerted in model cells. Milk EXOs enhanced the bioavailability and anticancer activity of CUR and RSV by acting as Trojan horses that escape from cancer cells’ ABC-mediated chemoresistance. Full article
(This article belongs to the Special Issue Dietary Bioactive Compounds and Breast Cancer II)
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Review

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30 pages, 4187 KiB  
Review
Anti-Cancer Potential of Edible/Medicinal Mushrooms in Breast Cancer
by Marzia Bruna Gariboldi, Emanuela Marras, Nicole Ferrario, Veronica Vivona, Pamela Prini, Francesca Vignati and Gianpaolo Perletti
Int. J. Mol. Sci. 2023, 24(12), 10120; https://doi.org/10.3390/ijms241210120 - 14 Jun 2023
Cited by 13 | Viewed by 14189
Abstract
Edible/medicinal mushrooms have been traditionally used in Asian countries either in the cuisine or as dietary supplements and nutraceuticals. In recent decades, they have aroused increasing attention in Europe as well, due to their health and nutritional benefits. In particular, among the different [...] Read more.
Edible/medicinal mushrooms have been traditionally used in Asian countries either in the cuisine or as dietary supplements and nutraceuticals. In recent decades, they have aroused increasing attention in Europe as well, due to their health and nutritional benefits. In particular, among the different pharmacological activities reported (antibacterial, anti-inflammatory, antioxidative, antiviral, immunomodulating, antidiabetic, etc.), edible/medicinal mushrooms have been shown to exert in vitro and in vivo anticancer effects on several kinds of tumors, including breast cancer. In this article, we reviewed mushrooms showing antineoplastic activity again breast cancer cells, especially focusing on the possible bioactive compounds involved and their mechanisms of action. In particular, the following mushrooms have been considered: Agaricus bisporus, Antrodia cinnamomea, Cordyceps sinensis, Cordyceps militaris, Coriolus versicolor, Ganoderma lucidum, Grifola frondosa, Lentinula edodes, and Pleurotus ostreatus. We also report insights into the relationship between dietary consumption of edible mushrooms and breast cancer risk, and the results of clinical studies and meta-analyses focusing on the effects of fungal extracts on breast cancer patients. Full article
(This article belongs to the Special Issue Dietary Bioactive Compounds and Breast Cancer II)
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23 pages, 1136 KiB  
Review
Phytochemical Targeting of Mitochondria for Breast Cancer Chemoprevention, Therapy, and Sensitization
by Elizabeth R. M. Zunica, Christopher L. Axelrod and John P. Kirwan
Int. J. Mol. Sci. 2022, 23(22), 14152; https://doi.org/10.3390/ijms232214152 - 16 Nov 2022
Cited by 5 | Viewed by 3227
Abstract
Breast cancer is a common and deadly disease that causes tremendous physical, emotional, and financial burden on patients and society. Early-stage breast cancer and less aggressive subtypes have promising prognosis for patients, but in aggressive subtypes, and as cancers progress, treatment options and [...] Read more.
Breast cancer is a common and deadly disease that causes tremendous physical, emotional, and financial burden on patients and society. Early-stage breast cancer and less aggressive subtypes have promising prognosis for patients, but in aggressive subtypes, and as cancers progress, treatment options and responses diminish, dramatically decreasing survival. Plants are nutritionally rich and biologically diverse organisms containing thousands of metabolites, some of which have chemopreventive, therapeutic, and sensitizing properties, providing a rich source for drug discovery. In this study we review the current landscape of breast cancer with a central focus on the potential role of phytochemicals for treatment, management, and disease prevention. We discuss the relevance of phytochemical targeting of mitochondria for improved anti-breast cancer efficacy. We highlight current applications of phytochemicals and derivative structures that display anti-cancer properties and modulate cancer mitochondria, while describing future applicability and identifying areas of promise. Full article
(This article belongs to the Special Issue Dietary Bioactive Compounds and Breast Cancer II)
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