Calmodulin Function in Health and Disease 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 16226
Special Issue Editors
Interests: calcium; calmodulin; cancer; receptor tyrosine kinases EGFR/ErbB1/HER1 and ErbB2/HER2; adaptor protein Grb7; and non-receptor tyrosine kinase Src
Special Issues, Collections and Topics in MDPI journals
Interests: cell signaling; cell cycle; cell proliferation; plasma membrane repair; cancer; calcium binding proteins; calmodulin; ALG-2
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Calmodulin is the major intracellular transducer of the Ca2+ signal in all eukaryotic cells, regulating a myriad of cellular processes by modulating the activity of hundreds of proteins, including enzymes, ion channels, transcription factors, receptors for different ligands, adaptors and structural proteins. The multifunctional role of this highly conserved protein is facilitated by its capacity to utilise different occupancy of its four Ca2+-binding sites with distinct affinities and binding kinetics, and its enormous structural flexibility. This allows for simultaneous linkage to distinct or identical proteins and/or two segments of the same protein, forming dimeric complexes or operational motifs with specific functional roles. Post-translational modifications of calmodulin, particularly its phosphorylation, add an additional layer of complexity to the functionality of calmodulin, allowing for drastic modification or subtle modulation of its multiple regulatory roles. In recent years, the discovery of calmodulin mutations in humans has uncovered its critical role in cardiac physiology and enabled new insights into the cause of different types of cardiac arrhythmias. These genetic alterations could be the cause of yet uncovered pathologies. It is expected that the study of calmodulin functionality in health and its dysfunction in disorders, including cancer, could help to identify new potential pharmacological targets to combat different diseases.
Prof. Dr. Antonio Villalobo
Prof. Dr. Martin W. Berchtold
Guest Editors
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Keywords
- Ca2+-dependent calmodulin functions
- Ca2+-independent calmodulin functions
- Posttranslational calmodulin modifications
- Calmodulin genetics
- Calmodulin mutations
- Calmodulin as adaptor
- Calmodulin-based Ca2+ sensors
- Calmodulin inhibitors
- Calmodulin biophysics
- Calmodulin in health and disease
- Calmodulin evolution