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Advancements in Drug Delivery Systems

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 2938

Special Issue Editor


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Guest Editor
School of Pharmaceutical Sciences, Wuhan University, Wuhan, China
Interests: microneedle; drug delivery; transdermal drug delivery; controlled release; skin cancer; long-acting

Special Issue Information

Dear Colleagues, 

Drug delivery systems have achieved great development in disease treatments in the last few decades. Conventional dosage forms, such as tablets, capsules, and transdermal gels, are usually associated with a low bioavailability, frequent application, side effects, and, hence, patient noncompliance. Novel drug delivery systems by integrating some strategies, such as enabling the controlled release of drug, helps to achieve localized delivery of therapeutics, provide targeted delivery of payloads, and offer attractive alternatives to traditional drug formulations.

Therefore, the Special Issue of International Journal of Molecular Science “Advancements in Drug Delivery Systems” will present the recent developments of drug delivery systems for disease treatments with the aim of enhancing knowledge of interaction of drugs, delivery systems, and therapies. We promote the submission of original research manuscripts and review articles relating to this topic.

Prof. Dr. Wei Li
Guest Editor

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Keywords

  • drug delivery
  • microneedle
  • nanoparticles
  • drug vehicles
  • controlled release
  • targeted delivery
  • localized delivery

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Published Papers (1 paper)

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Research

14 pages, 3516 KiB  
Article
Cryogenic 3D Printing of w/o Pickering Emulsions Containing Bifunctional Drugs for Producing Hierarchically Porous Bone Tissue Engineering Scaffolds with Antibacterial Capability
by Xinliang Ye, Zhi He, Yuming Liu, Xiaoying Liu, Rouye He, Ganhang Deng, Ziqing Peng, Jiayu Liu, Zicai Luo, Xiaoling He, Xiang Wang, Jing Wu, Xiaowei Huang, Jingying Zhang and Chong Wang
Int. J. Mol. Sci. 2022, 23(17), 9722; https://doi.org/10.3390/ijms23179722 - 27 Aug 2022
Cited by 8 | Viewed by 2382
Abstract
How to fabricate bone tissue engineering scaffolds with excellent antibacterial and bone regeneration ability has attracted increasing attention. Herein, we produced a hierarchical porous β-tricalcium phosphate (β-TCP)/poly(lactic-co-glycolic acid)-polycaprolactone composite bone tissue engineering scaffold containing tetracycline hydrochloride (TCH) through a micro-extrusion-based cryogenic 3D printing [...] Read more.
How to fabricate bone tissue engineering scaffolds with excellent antibacterial and bone regeneration ability has attracted increasing attention. Herein, we produced a hierarchical porous β-tricalcium phosphate (β-TCP)/poly(lactic-co-glycolic acid)-polycaprolactone composite bone tissue engineering scaffold containing tetracycline hydrochloride (TCH) through a micro-extrusion-based cryogenic 3D printing of Pickering emulsion inks, in which the hydrophobic silica (h-SiO2) nanoparticles were used as emulsifiers to stabilize composite Pickering emulsion inks. Hierarchically porous scaffolds with desirable antibacterial properties and bone-forming ability were obtained. Grid scaffolds with a macroscopic pore size of 250.03 ± 75.88 μm and a large number of secondary micropores with a diameter of 24.70 ± 15.56 μm can be fabricated through cryogenic 3D printing, followed by freeze-drying treatment, whereas the grid structure of scaffolds printed or dried at room temperature was discontinuous, and fewer micropores could be observed on the strut surface. Moreover, the impartment of β-TCP in scaffolds changed the shape and density of the micropores but endowed the scaffold with better osteoconductivity. Scaffolds loaded with TCH had excellent antibacterial properties and could effectively promote the adhesion, expansion, proliferation, and osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells afterward. The scaffolds loaded with TCH could realize the strategy to “kill bacteria first, then induce osteogenesis”. Such hierarchically porous scaffolds with abundant micropores, excellent antibacterial property, and improved bone-forming ability display great prospects in treating bone defects with infection. Full article
(This article belongs to the Special Issue Advancements in Drug Delivery Systems)
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