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Therapeutic Aspects of Gasotransmitters in Cardiovascular and Renal Disease 2.0
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Therapeutic Aspects of Gasotransmitters in Cardiovascular and Renal Disease 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (15 November 2022) | Viewed by 8037

Special Issue Editors

Prof. Dr. Jaap A. Joles

E-Mail Website
Guest Editor
Department of Nephrology and Hypertension, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands
Interests: cardiorenal syndrome; uremic animal models; regenerative nephrology; renal hypoxia; gasotransmitters; developmental renal programming; diabetic kidney disease; portable dialysis
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Harry van Goor

E-Mail Website
Guest Editor
Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands
Interests: oxidative stress; biomarkers; thiosulfate; hydrogen sulfide
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Gasotransmitters (NO, CO and H2S) are protective in various conditions because of their vasodilatory, anti-inflammatory, antioxidant, and antifibrotic characteristics. They exert their effects via signal transduction via guanylate cyclase and cGMP in many tissues. Another protective pathway involves signaling via the Nrf2/keap1pathway. Moreover, all three gasotransmitters inhibit mitochondrial respiration and reduce ROS production.

Well-known pharmacological strategies involving NO include NO donors for pulmonary hypertension and phosphodiesterase inhibitors for erectile dysfunction. Sodium thiosulfate, an H2S donor that appears useful in calciphylaxis in end-stage kidney disease, is now in phase III for cardiac ischemic events. Therapeutic use of CO, for instance with CO donors, is in its infancy. This Special Issue focuses on “Therapeutic Aspects of Gasotransmitters in Cardiovascular and Renal Disease”. Different donor compounds have a wide range of kinetics. Various compounds target signaling pathways. Tolerance is well-recognized for NO donors but has barely been addressed for CO. Data on thiosulfate tolerance have recently been reported. The interdependency of cardiac, renal, and vascular function, as well as their involvement in systemic conditions, such as diabetes and pre-eclampsia, encourage an integrative systems approach. Original studies (preclinical and clinical), with an emphasis on molecular biology and molecular medicine, as well as reviews, are all welcome.

Prof. Dr. Jaap A. Joles
Prof. Dr. Harry van Goor
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nitric oxide
  • carbon monoxide
  • hydrogen sulfide
  • guanylate cyclase
  • hypertension
  • chronic kidney disease
  • heart failure
  • atherosclerosis

Published Papers (3 papers)

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Research

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24 pages, 1727 KiB  
Article
Redox and Nucleophilic Reactions of Naphthoquinones with Small Thiols and Their Effects on Oxidization of H2S to Inorganic and Organic Hydropolysulfides and Thiosulfate
by Kenneth R. Olson, Kasey J. Clear, Yan Gao, Zhilin Ma, Nathaniel M. Cieplik, Alyssa R. Fiume, Dominic J. Gaziano, Stephen M. Kasko, Jennifer Luu, Ella Pfaff, Anthony Travlos, Cecilia Velander, Katherine J. Wilson, Elizabeth D. Edwards, Karl D. Straub and Gang Wu
Int. J. Mol. Sci. 2023, 24(8), 7516; https://doi.org/10.3390/ijms24087516 - 19 Apr 2023
Cited by 1 | Viewed by 1491
Abstract
Naphthoquinone (1,4-NQ) and its derivatives (NQs, juglone, plumbagin, 2-methoxy-1,4-NQ, and menadione) have a variety of therapeutic applications, many of which are attributed to redox cycling and the production of reactive oxygen species (ROS). We previously demonstrated that NQs also oxidize hydrogen sulfide (H [...] Read more.
Naphthoquinone (1,4-NQ) and its derivatives (NQs, juglone, plumbagin, 2-methoxy-1,4-NQ, and menadione) have a variety of therapeutic applications, many of which are attributed to redox cycling and the production of reactive oxygen species (ROS). We previously demonstrated that NQs also oxidize hydrogen sulfide (H2S) to reactive sulfur species (RSS), potentially conveying identical benefits. Here we use RSS-specific fluorophores, mass spectroscopy, EPR and UV-Vis spectrometry, and oxygen-sensitive optodes to examine the effects of thiols and thiol-NQ adducts on H2S-NQ reactions. In the presence of glutathione (GSH) and cysteine (Cys), 1,4-NQ oxidizes H2S to both inorganic and organic hydroper-/hydropolysulfides (R2Sn, R=H, Cys, GSH; n = 2–4) and organic sulfoxides (GSnOH, n = 1, 2). These reactions reduce NQs and consume oxygen via a semiquinone intermediate. NQs are also reduced as they form adducts with GSH, Cys, protein thiols, and amines. Thiol, but not amine, adducts may increase or decrease H2S oxidation in reactions that are both NQ- and thiol-specific. Amine adducts also inhibit the formation of thiol adducts. These results suggest that NQs may react with endogenous thiols, including GSH, Cys, and protein Cys, and that these adducts may affect both thiol reactions as well as RSS production from H2S. Full article
(This article belongs to the Special Issue Therapeutic Aspects of Gasotransmitters in Cardiovascular and Renal Disease 2.0)
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Review

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18 pages, 1296 KiB  
Review
Gasotransmitters for the Therapeutic Prevention of Hypertension and Kidney Disease
by Chien-Ning Hsu and You-Lin Tain
Int. J. Mol. Sci. 2021, 22(15), 7808; https://doi.org/10.3390/ijms22157808 - 21 Jul 2021
Cited by 12 | Viewed by 2825
Abstract
Nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S), three major gasotransmitters, are involved in pleiotropic biofunctions. Research on their roles in hypertension and kidney disease has greatly expanded recently. The developing kidney can be programmed by various adverse in [...] Read more.
Nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S), three major gasotransmitters, are involved in pleiotropic biofunctions. Research on their roles in hypertension and kidney disease has greatly expanded recently. The developing kidney can be programmed by various adverse in utero conditions by so-called renal programming, giving rise to hypertension and kidney disease in adulthood. Accordingly, early gasotransmitter-based interventions may have therapeutic potential to revoke programming processes, subsequently preventing hypertension and kidney disease of developmental origins. In this review, we describe the current knowledge of NO, CO, and H2S implicated in pregnancy, including in physiological and pathophysiological processes, highlighting their key roles in hypertension and kidney disease. We summarize current evidence of gasotransmitter-based interventions for prevention of hypertension and kidney disease in animal models. Continued study is required to assess the interplay among the gasotransmitters NO, CO, and H2S and renal programming, as well as a greater focus on further clinical translation. Full article
(This article belongs to the Special Issue Therapeutic Aspects of Gasotransmitters in Cardiovascular and Renal Disease 2.0)
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15 pages, 6187 KiB  
Review
Donor Heart Preservation with Hydrogen Sulfide: A Systematic Review and Meta-Analysis
by Imran A. Ertugrul, Vincent van Suylen, Kevin Damman, Marie-Sophie L. Y. de Koning, Harry van Goor and Michiel E. Erasmus
Int. J. Mol. Sci. 2021, 22(11), 5737; https://doi.org/10.3390/ijms22115737 - 27 May 2021
Cited by 10 | Viewed by 2768
Abstract
Preclinical studies have shown that postconditioning with hydrogen sulfide (H2S) exerts cardioprotective effects against myocardial ischemia-reperfusion injury (IRI). The aim of this study was to appraise the current evidence of the cardioprotective effects of H2S against IRI in order [...] Read more.
Preclinical studies have shown that postconditioning with hydrogen sulfide (H2S) exerts cardioprotective effects against myocardial ischemia-reperfusion injury (IRI). The aim of this study was to appraise the current evidence of the cardioprotective effects of H2S against IRI in order to explore the future implementation of H2S in clinical cardiac transplantation. The current literature on H2S postconditioning in the setting of global myocardial ischemia was systematically reviewed and analyzed, performing meta-analyses. A literature search of the electronic databases Medline, Embase and Cinahl identified 1835 studies that were subjected to our pre-defined inclusion criteria. Sixteen studies were considered eligible for inclusion. Postconditioning with H2S showed significant robust effects with regard to limiting infarct size (standardized mean difference (SMD) = −4.12, 95% CI [−5.53–−2.71], p < 0.00001). Furthermore, H2S postconditioning consistently resulted in a significantly lower release of cardiac injury markers, lower levels of oxidative stress and improved cardiac function. Postconditioning with slow-releasing H2S donors offers a valuable opportunity for novel therapies within cardiac preservation for transplantation. Before clinical implication, studies evaluating the long-term effects of H2S treatment and effects of H2S treatment in large animal studies are warranted. Full article
(This article belongs to the Special Issue Therapeutic Aspects of Gasotransmitters in Cardiovascular and Renal Disease 2.0)
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