Advances in Oxidative Stress, Placental Hypoxia, and Preeclampsia
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Reproductive and Developmental Biology".
Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 237
Special Issue Editors
Interests: placenta; preeclampsia; oxidative stress; magnesium therapy
Interests: membrane transport; diabetes; pregnancy; obesity; vascular; cell signalling; insulin
Interests: oxidative stress; biomarkers; thiosulfate; hydrogen sulfide
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Preeclampsia is a pregnancy-specific clinical syndrome that leads to fetal, neonatal, and maternal morbidity and mortality. Oxidative stress is an imbalance between the generation of reactive oxygen species (ROS) or reactive nitrogen species (RNS) and the cellular antioxidant capacity. The placenta is the primary source of ROS during pregnancy. It is well-known that the antioxidant capacity is affected in women with preeclampsia, leading to an imbalance between the existing pro-oxidant and antioxidant systems, resulting in oxidative stress. Oxidative stress of the syncytiotrophoblast is one of the critical features of preeclampsia. Dysfunction of the fetoplacental endothelium is also considered a factor contributing to or resulting from preeclampsia. There are different hypotheses about the aetiology of preeclampsia. However, the specific mechanisms that trigger and maintain this syndrome are still uncertain. The consensus is that preeclampsia is started either by specific trophoblast defects or maternal metabolic defects. Although studies in animal models of preeclampsia indicate that placental hypoxia is associated with harmful effects at systemic, placental, and fetal levels, other studies do not seem to link this process to the development of preeclampsia. This Special Issue will bring together research addressing new insights into oxidative stress, placental hypoxia, and preeclampsia.
This Special Issue welcomes original research articles, clinical studies, reviews, and perspectives toward understanding the link between placental hypoxia, oxidative stress, and preeclampsia.
Specific themes include, but are not limited to:
- Placental hypoxia.
- Oxidative stress and preeclampsia.
- Antioxidants and preeclampsia.
- Mitochondrial dysfunction and preeclampsia.
- Antioxidant defense and preeclampsia.
- Biomarkers of oxidative stress and preeclampsia.
- Nuclear factor erythroid 2-related factor 2 (NRF2), oxidative stress and preeclampsia.
- Fetal growth restriction and oxidative stress.
- Syncytiotrophoblast stress and preeclampsia.
- Fetoplacental endothelial dysfunction and preeclampsia.
Prof. Dr. Reinaldo Marín
Prof. Dr. Luis Sobrevia
Prof. Dr. Harry van Goor
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- placenta
- hypoxia
- oxidative stress
- preeclampsia
- syncytiotrophoblast
