Gut Microbes and Gut Metabolites
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".
Deadline for manuscript submissions: closed (30 April 2021) | Viewed by 76863
Special Issue Editor
Special Issue Information
Dear Colleagues,
The scope of this special issue is to compile a series of original research papers and reviews that demonstrate a link between dietary metabolite products* and an improvement in human health indicators.
Interventions can provide microbes (probiotics) or foods/ supplements with components such as flavonoids, phenolic compounds or non-digestible carbohydrates (prebiotics) in the diet with the aim of effecting positive changes in the gut microbiota. Several general mechanisms have been established by which the gut bacteria or their major products (short chain fatty acids) can affect aspects of the host’s biology including the immune system, gut barrier function and energy metabolism. However, the mechanisms by which specific probiotics or prebiotics act are much less established.
Some of the microbial metabolite products - degradation products of polyphenols, complex carbohydrates, dietary protein and amino acids - and endogenous metabolites related to energy pathways (Krebs cycle, glycolysis, beta-oxidation) and those involved in digestion (bile acids) have the capacity to interact with the microbiome, leading potentially to a net positive balance in health or at least to a sustainable homeostasis.
In vivo and in vitro studies on host metabolism (lipid and energy pathways) and involvement of microbiota will be particularly welcome.
This special issue will offer experts in the field the opportunity to display the latest results in nutritional metabolomics/lipidomics and review the current developments while providing the readers with an exciting prospect of new possibilities in preventive medicine and precision nutrition research.
* phenolic compounds, short chain fatty acids, biogenic amines, etc.
Dr. Gwenaelle Le Gall
Guest Editor
Manuscript Submission Information
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Keywords
- gut metabolites
- metabolism
- phenolic compounds
- short chain fatty acids
- metabolomics
- lipidomics
- prebiotics
- probiotics
- microbiota
- health
- nutrition
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