Hematopoietic Stem Cells, Metabolic Regulations, and Aging
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 28698
Special Issue Editors
Interests: blood stem cell transplantation; biology and cell divisions of stem cells – control mechanisms of self-renewal versus differentiation; aging and senescence of HSC
Interests: Hematopoietic stem cells; Aging; Metabolism; Glucose metabolism; Cellular senescence; Epigenetic dysregulation; Genomics, transcriptomics, and proteomics; Mitochondrial aging; Fatty acid metabolism; Autophagy; Clonal proliferation by aging
Special Issue Information
Dear Colleagues,
In the 1920s Otto Warburg discovered that cancer cells consumed enormous amount of glucose to fuel their accelerated metabolism. He believed that tumors could be treated by controlling aerobic versus anaerobic glycolysis. In the meantime, changes in metabolism have been shown to regulate cell signaling, gene expression, cellular fate and tissue function. Metabolic perturbations impair cellular differentiation, long-term fate, and play a major role in aging as well as in malignant transformation. The theme of this Special Issue focuses on metabolic regulation of self-renewal and differentiation, and on how disrupted metabolism can result in dysregulation, aging, cellular senescence, and malignant transformation. Topics will include – but need not be confined to – how metabolites impact developmental decisions in hematopoietic stem cells and their niche, how mitochondrial and lysosomal function affect stem cell aging, the epigenetic roles of metabolites, signaling roles of metabolites across stem cells and their niche, and the impact of metabolic interventions in aging and disease. Our aim is to foster collaborations across a range of disciplines and ultimately how interventions in metabolic pathways may modulate the aging process.
Prof. Dr. Anthony Dick Ho
Prof. Dr. Toshio Suda
Guest Editors
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Keywords
- Hematopoietic stem cells
- Aging
- Metabolism
- Glucose metabolism
- Fatty acid metabolism
- Cellular senescence
- Epigenetic dysregulation
- Genomics, transcriptomics, and proteomics
- Mitochondrial aging
- Autophagy
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