Mast Cells: From Host Defense to Pathology 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 7080
Special Issue Editor
Interests: immunoreceptors; adaptor molecules; signal transduction; regulation of immune system; mast cells; allergy; anaphylaxis; KIT oncogenic disorders
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
For this Special Issue of the International Journal of Molecular Sciences, we invite you to contribute either an original research article or a review article on any aspect of the subject of “Mast Cells: From Host Defense to Pathology”. Articles that provide mechanistic and functional insights at either a cellular or a molecular level, both in vitro and in vivo, are particularly welcome.
The evolutionary role of mast cells has been to act as a first line of defense against parasites and venoms. For this reason, they are found predominantly at the interface between the host and the external environment, at places of potential entry of pathogens or that are in contact with harmful substances. They express a wide spectrum of cell surface receptors, including immunoglobulin Fc receptors, toll-like receptors for pattern recognition, and other innate receptors, that enable them to respond to endogenous mediators and exogenous stimuli to release immune mediators to overcome the insult. However, mast cells are best known and widely recognized for their role in pathology as they are the main effector cell in allergies and anaphylaxis, a severe allergic reaction that may cause death. In the last few decades, the incidence of allergies and anaphylaxis has risen at an alarming rate and continues to rise. Therefore, a better understanding of the molecular basis for mast cell function will have repercussions that range from host defense to pathology.
Prof. Dr. Margarita Martín
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- mast cells
- bacteria
- virus
- host defense
- allergy
- anaphylaxis
- molecular mechanisms
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.