Genetic and Molecular Mechanisms in Primary Headache and Treatment
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (17 November 2023) | Viewed by 9870
Special Issue Editors
Interests: genetics; migraine; cluster headache; gene expression; pharmacogenetics; neuroscience
Special Issues, Collections and Topics in MDPI journals
Interests: genetics; headache; neuroscience; pain; circadian rhythm; neurology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Primary headache disorders are recognized as recurrent, medium to severe headaches that have no known underlying cause. These disorders have repeatedly been estimated to be one of the primary causes of years lived with disability by the WHO (world health organization). Fifty percent of the global population is approximated to suffer from primary headache disorders, most commonly tension-type headaches, migraine and trigeminal autonomic cephalalgias (TACs). Nevertheless, headache disorders are still underdiagnosed and undertreated. Genetic research on primary headache disorders has greatly advanced the research field in the last couple of years. In particular by performing genome-wide association studies (GWAS) on migraine and cluster headache (the most common TAC subtype). Numerous genetic loci have been associated with specific headache subtypes, as well as broadly defined headaches, and have also been linked to drug targets specific for headache treatments such as CGRP and triptans.
Genetic and molecular studies are key to discovering and deciphering the pathophysiological mechanisms underlying a disorder, finding biomarkers, refining diagnosis, developing new and more efficient treatments, and ultimately improving medical care. Further genetic and molecular studies will be crucial to develop and build on the current state of knowledge of headache pathophysiology. Accordingly, this Special Issue of the International Journal of Molecular Sciences welcomes submissions with a focus on genetic and molecular mechanisms that may be involved in headache pathophysiology and treatment mechanisms.
Dr. Caroline Ran
Dr. Andrea Carmine Belin
Guest Editors
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Keywords
- primary headache disorder
- cluster headache
- triptans
- CGPR
- nitric oxide
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