Regulation of Metabolism by Cell Cycle Regulators

Dear Colleagues,

In mammals, the cell cycle regulatory machinery is composed of about 20 different cyclin-dependent kinases (CDKs), which, together with their partners, cyclins, form complexes that activate or inhibit various substrates by phosphorylation. In addition, there are numerous specific inhibitors and activators of these complexes. The importance of these complexes is evident, because their miss-regulation may lead to some pathophysiological processes such as cancer. However, only one CDK is essential for the proper control of cell cycle progression. Thus, the emerging question is what is the purpose of the other CDKs and cell cycle members? The answer can be found in new physiological functions, in addition to cell cycle regulation, because during evolution, cell cycle proteins acquire new functions that go beyond driving the cell cycle, such as regulating the cell metabolism in certain cell types or specific environmental situations.

The aim of this Special Issue of IJMS is to cover new insights into the mechanisms regulated by the cell cycle machinery beyond cell cycle regulation. Important topics of this Special Issue also involve the role of CDKs, cyclins, and their inhibitors and activators in energy processes, endocrine regulation, inflammation, and metabolism, as well as the possibility of targeting these proteins in therapeutics and clinical applications. Original investigations in preclinical models and/or translational human studies, as well as reviewing manuscripts, are cordially invited for this Special Issue.

Dr. Escoté Xavier
Guest Editor

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