Systems Biologic Implications of Metronomic Therapies in Cancer and Hematologic Neoplasia
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (30 November 2019) | Viewed by 270
Special Issue Editors
Interests: cancer biology; anakoinosis; oncology; hematological malignancies
Special Issues, Collections and Topics in MDPI journals
Interests: genomics; next generation sequencing; inflammation; transcriptomics; macrophage activation
Interests: cell culture; cancer biology; flow cytometry; cell signaling; apoptosis; cell proliferation; antioxidants; reactive oxygen species; oxidative stress; cytotoxicity; lipid peroxidation; cell death; GSH; redox signaling
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Metronomic tumor therapy is the administration of drugs at the minimum biologically effective dose still leading to anti-tumor activity, given as a continuous dosing regimen with minimal drug-free breaks.
Well-tolerated by patients, metronomic regimens induce cancer cell reprogramming, ameliorating aberrant cancer tissue homeostasis, through cell-autonomous, tissue-autonomous, and systemic signalling, involving epithelial, stroma, and immune infiltrates, promoting long-term tumor control.
Reprogramming actions place metronomic therapy within emerging clinical approaches such as immunotherapy and anakoinosis, which promise durable responses by communicative reprogramming of tumor tissues and can be included in the ‘master modulators’ category of anticancer bio-modulatory drugs, i.e., transcriptional modulators; epigenetically modifying agents; and protein binding drugs, such as COX-2 inhibitors, IMiDs, metronomic chemotherapy, etc. Master modulators may mediate multi-level systems biologic effects on quite different topographic levels: the tumor’s different cell compartments; the tumor and the tumor-harboring organ; and, finally, the tumor and the whole organism.
A long record shows excellent clinical results for metronomic therapy in metastatic cancer. However, it is mostly unknown how bio-modulation is mechanistically achieved; this impairs focusing to improve the treatment.
The aim of this Special Issue is covering the multi-level effects of metronomic therapies in cancer and hematologic neoplasia to explore the mechanisms of bio-modulation.
In particular, we welcome topics covering the interaction of ‘master modulators’ with the tumor, the tumor-harboring organ, and the organism:
- The bio-modulatory effects of metronomic therapy
- The role of stroma and immune infiltrates in the bio-modulatory effect of metronomic regimens
- The establishment of in vitro advanced tissue culture models for the study of metronomic therapy
- The mathematical modeling of metronomic therapy
- Mechanisms of the effects of low vs. high doses of anticancer drugs
- Drug repurposing in metronomic chemotherapy
- Metronomic therapy redirecting immune responses in the tumor compartment
- The modulation of tumor-associated angiogenesis by metronomic therapy
- The control of tumor-associated inflammation by metronomic therapy
- Metronomic therapy and the up-regulation of non-mutated tumor suppressor genes
- Epigenetic changes following metronomic approaches
- The relationship between metronomic therapy and other bio-modulatory anticancer approaches
- The specification and improvment response by combining ‘master modulators’
- Anakoinosis as a novel paradigm for cancer treatment: communicative reprogramming of homeostatic pathways and the induction of evolutionary conserved functions
Prof. Dr. Lina Ghibelli
Dr. Daniel Heudobler
Prof. Dr. Albrecht Reichle
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- Interferon-alpha
- Peroxisome-proliferator activated receptor alpha/gamma agonists
- Glucocorticoids
- All-trans retinoic acid
- Arsenic trioxide
- IMiDs
- COX-2 inhibitors
- Metronomic chemotherapy
- Epigenetically modifying agents, i.e., azacitidine, decitabine, etc.
- Liposomal encapsulated small oligonucleotide encoding small activating RNAs
- Combinations of master modulators
- Master modulators plus classic targeted therapy
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.