The Interplay of Microbiome and Immune Response in Health and Diseases-2nd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (30 November 2021) | Viewed by 46588
Special Issue Editor
Interests: microbiota-immunity axis; autoimmunity; cancers; inflammation; T cells; micro and nanoplastic effects on human
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Increasing evidence suggests that microbiota plays a key role in human physiology, spanning from intestinal to brain activities and directly influencing several molecular pathways. Recent findings indicate how dysbiosis, a disproportion in the composition and organization of microbial populations, could severely impact in the development of different medical conditions (from metabolic to mood disorders), providing new insight for the comprehension of diverse diseases, such as IBD, obesity, asthma, autism spectrum disorders, stroke, diabetes, and cancer. Given that microbial cells in the gut outnumber cells of the host, microbiota influences human physiology functionally and structurally. Microbial metabolites bridge various, even distant, areas of the organism, by way of the immune and hormone system. For instance, it is now clear that the mutual interaction between the gastrointestinal tract and the brain, the so called gut-brain axis, often involves gut microbiota, indicating that the crosstalk between the organism and its microbial residents represents a fundamental aspect of both establishment and maintenance of healthy conditions. Moreover it is crucial to recognize that microbiota is not localized only in the gut. Both commensal and pathogenic organisms populate, beyond the intestinal tract, other organs and tissues (e.g., skin and oral mucosa) of the “host”. This Special Issue will be dedicated to the impact of microbiota on human health physiology and pathology, welcoming all those studies that will help to clarify how microorganisms interact with their hosts, if there are tissue-specific interactions and what are the effects of their presence, absence or imbalance.
Prof. Dr. Amedeo Amedei
Guest Editor
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Keywords
- microbiota
- dysbiosis
- inflammatory
- immune system
- gut-brain axis
- probiotics
- microbial metabolites
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