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Molecular Pathogenesis and Therapies for Autoimmune Blistering Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: closed (31 January 2023) | Viewed by 2063

Special Issue Editor


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Guest Editor
Division of Dermatology, Rush University, Chicago, IL 60612, USA
Interests: autoimmune blistering disease; immune–epidermal interactions; mitigating steroid induced comorbidities; autoimmune blistering diseases; dermatology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

Autoimmune blistering diseases are a group of potentially fatal conditions caused by the development of autoantibodies to various antigens in the skin. Through improved insight into the pathogenesis of these diseases, numerous therapies are currently in development to treat them. These therapies not only target the production and circulation of autoantibodies, but immune regulation as well. As such, autoimmune blistering diseases are seeing an increase in targeted therapies that will hopefully minimize the severe side effects inflicted by oral corticosteroids. In this Special Issue, we will highlight recent advances in our understanding of the pathogenesis of these diseases, as well as recent therapeutic advances.

Dr. Kyle T. Amber
Guest Editor

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Keywords

  • pemphigus
  • pemphigoid
  • epidermolysis bullosa acquisita
  • linear IgA bullous dermatosis
  • autoimmune blistering disease
  • immunobullous disease
  • paraneoplastic autoimmune multiorgan syndrome

Published Papers (1 paper)

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Research

13 pages, 2614 KiB  
Article
Expression of the Selected Proteins of JAK/STAT Signaling Pathway in Diseases with Oral Mucosa Involvement
by Kamila Ociepa, Marian Danilewicz, Małgorzata Wągrowska-Danilewicz, Róża Peterson-Jęckowska, Angelika Wójcicka-Rubin, Natalia Lewkowicz, Radosław Zajdel and Agnieszka Żebrowska
Int. J. Mol. Sci. 2023, 24(1), 323; https://doi.org/10.3390/ijms24010323 - 24 Dec 2022
Cited by 4 | Viewed by 1699
Abstract
The JAK/STAT signal pathway is a system of intracellular proteins used by many cytokines and growth factors to express genes responsible for the process of cell activation, proliferation and differentiation. There has been numerous inflammatory and autoimmune diseases identified where the JAK/STAT signaling [...] Read more.
The JAK/STAT signal pathway is a system of intracellular proteins used by many cytokines and growth factors to express genes responsible for the process of cell activation, proliferation and differentiation. There has been numerous inflammatory and autoimmune diseases identified where the JAK/STAT signaling is disrupted; however, there are only a few papers concerning autoimmune bullous diseases published. The aim of this study was to evaluate the expression of proteins: JAK3, STAT2, STAT4 and STAT6 in epithelium lesions in patients with pemphigus vulgaris (PV), bullous pemphigoid (BP), oral lichen planus (LP) and chronic ulcerative stomatitis (CUS), as well as in the control group. Immunohistochemistry and immunoblotting were used to evaluate expression of selected proteins. We found significantly higher expression of selected JAK/STAT proteins in oral mucosa lesions in study groups in comparison to the control group, which indicates participation of JAK/STAT pathway in pathogenesis of these diseases. In BP and PV there were no increased STAT2 expression, whereas in CUS and LP no increased STAT4 expression occurred. The differences in expression of JAK/STAT proteins in selected disorders have been observed. These results create new potential therapeutic targets for the treatment. Full article
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