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Molecular Characteristics of Renal Cell Carcinoma
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Molecular Characteristics of Renal Cell Carcinoma

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: closed (31 January 2022) | Viewed by 16753

Special Issue Editor

Dr. David Meierhofer

E-Mail Website
Guest Editor
Max Planck Institute for Molecular Genetics, Berlin, Germany
Interests: renal cell carcinoma; mitochondrial diseases; mass spectrometry; proteomics; metabolomics

Special Issue Information

Dear Colleagues,

Renal cell carcinoma (RCC) represents approximately 4% of adult malignancies and was ranked as the sixth-deadliest cancer worldwide. RCC can be classified according to distinct morphologic and molecular genetic features and is composed of different subtypes, such as clear cell RCC (ccRCC), papillary RCC (pRCC), chromophobe RCC (chRCC), and benign renal oncocytomas (RO). Efforts are being undertaken to characterize these tumor entities on different omics levels. The large datasets produced can be used (and should be re-used by others) to generate new hypotheses about origin, progression, and therapeutic strategies.

This Special Issue aims to highlight the importance of molecular insights for the elucidation of disease mechanisms in RCC. Authors are invited to submit original articles that relate to, but are not limited to, the application of integrative studies with basic research or clinical relevance, as well as targeted reviews of the current limitations and future developments in this exciting research area.

Dr. David Meierhofer
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Renal cell carcinoma (RCC)
  • Clear cell RCC
  • Papillary RCC
  • Chromophobe RCC
  • Renal oncocytoma
  • Mass spectrometry
  • Proteomics
  • Metabolomics
  • Transcriptomics
  • Metabolic pathways
  • Gene mMutations

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Published Papers (3 papers)

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Review

35 pages, 527 KiB  
Review
Renal Oncocytoma: The Diagnostic Challenge to Unmask the Double of Renal Cancer
by Francesco Trevisani, Matteo Floris, Roberto Minnei and Alessandra Cinque
Int. J. Mol. Sci. 2022, 23(5), 2603; https://doi.org/10.3390/ijms23052603 - 26 Feb 2022
Cited by 13 | Viewed by 6058
Abstract
Renal oncocytoma represents the most common type of benign neoplasm that is an increasing concern for urologists, oncologists, and nephrologists due to its difficult differential diagnosis and frequent overtreatment. It displays a variable neoplastic parenchymal and stromal architecture, and the defining cellular element [...] Read more.
Renal oncocytoma represents the most common type of benign neoplasm that is an increasing concern for urologists, oncologists, and nephrologists due to its difficult differential diagnosis and frequent overtreatment. It displays a variable neoplastic parenchymal and stromal architecture, and the defining cellular element is a large polygonal, granular, eosinophilic, mitochondria-rich cell known as an oncocyte. The real challenge in the oncocytoma treatment algorithm is related to the misdiagnosis due to its resemblance, at an initial radiological assessment, to malignant renal cancers with a completely different prognosis and medical treatment. Unfortunately, percutaneous renal biopsy is not frequently performed due to the possible side effects related to the procedure. Therefore, the majority of oncocytoma are diagnosed after the surgical operation via partial or radical nephrectomy. For this reason, new reliable strategies to solve this issue are needed. In our review, we will discuss the clinical implications of renal oncocytoma in daily clinical practice with a particular focus on the medical diagnosis and treatment and on the potential of novel promising molecular biomarkers such as circulating microRNAs to distinguish between a benign and a malignant lesion. Full article
(This article belongs to the Special Issue Molecular Characteristics of Renal Cell Carcinoma)
13 pages, 588 KiB  
Review
Characteristics of Clear Cell Papillary Renal Cell Carcinoma (ccpRCC)
by Jacek Rysz, Beata Franczyk, Janusz Ławiński and Anna Gluba-Brzózka
Int. J. Mol. Sci. 2022, 23(1), 151; https://doi.org/10.3390/ijms23010151 - 23 Dec 2021
Cited by 21 | Viewed by 5319
Abstract
Renal cell carcinomas (RCCs) is a group of various malignant tumours of the renal cortex displaying distinct clinical, morphologic, and genetic features. Clear cell papillary renal cell carcinoma (ccpRCC), belonging to this group, shares morphologic features with both clear cell renal cell carcinoma [...] Read more.
Renal cell carcinomas (RCCs) is a group of various malignant tumours of the renal cortex displaying distinct clinical, morphologic, and genetic features. Clear cell papillary renal cell carcinoma (ccpRCC), belonging to this group, shares morphologic features with both clear cell renal cell carcinoma (ccRCC) and papillary renal cell carcinoma (pRCC) and therefore, more strict diagnostic criteria should be developed to avoid misdiagnosis. Despite overlapping features, ccpRCC has also distinct clinical behaviour, histologic characteristics (morphologic and immunohistochemical), and genomic features. The concepts concerning this tumour are constantly developing since its biological potential and molecular basis remains to be fully unravelled. First reports indicated the presence of ccpRCC in end-stage renal disease, and they underlined the enriched development in this group of patients; however, currently, it is known that such tumours can also occur spontaneously in the normal kidney. Numerous studies have demonstrated that clinical outcomes and prognosis of ccpRCC patients is highly favourable. Till now, no convincing evidence of metastatic ccpRCC or death caused by the disease has been found. Therefore, it is of high importance to correctly differentiate ccpRCC from other subtypes of RCC with a much worse prognosis and to introduce appropriate management. Full article
(This article belongs to the Special Issue Molecular Characteristics of Renal Cell Carcinoma)
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22 pages, 1327 KiB  
Review
The Molecular Characteristics of Non-Clear Cell Renal Cell Carcinoma: What’s the Story Morning Glory?
by Andrea Marchetti, Matteo Rosellini, Veronica Mollica, Alessandro Rizzo, Elisa Tassinari, Giacomo Nuvola, Alessia Cimadamore, Matteo Santoni, Michelangelo Fiorentino, Rodolfo Montironi and Francesco Massari
Int. J. Mol. Sci. 2021, 22(12), 6237; https://doi.org/10.3390/ijms22126237 - 9 Jun 2021
Cited by 16 | Viewed by 4576
Abstract
Non-clear cell renal cell carcinomas are a miscellaneous group of tumors that include different histological subtypes, each one characterized by peculiarity in terms of genetic alteration, clinical behavior, prognosis, and treatment response. Because of their low incidence and poor enrollment in clinical trials, [...] Read more.
Non-clear cell renal cell carcinomas are a miscellaneous group of tumors that include different histological subtypes, each one characterized by peculiarity in terms of genetic alteration, clinical behavior, prognosis, and treatment response. Because of their low incidence and poor enrollment in clinical trials, alongside their heterogeneity, additional efforts are required to better unveil the pathogenetic mechanisms and, consequently, to improve the treatment algorithm. Nowadays, tyrosine kinase inhibitors, mTOR and MET inhibitors, and even cisplatin-based chemotherapy and immunotherapy are potential weapons that are still under evaluation in this setting. Various biomarkers have been evaluated for detecting progression and monitoring renal cell carcinoma, but more studies are necessary to improve this field. In this review, we provide an overview on the molecular characteristics of this group of tumors and the recently published trials, giving an insight into what might become the future therapeutic standard in this complex world of non-clear cell kidney cancers. Full article
(This article belongs to the Special Issue Molecular Characteristics of Renal Cell Carcinoma)
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