ijms-logo

Journal Browser

Journal Browser

Myocardial Disease: Molecular Pathology and Treatments

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 581

Special Issue Editor


E-Mail Website
Guest Editor
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan
Interests: fish oil; postprandial hyperlipidemia; antioxidants; heart failure; hyperlipidemia; atherosclerosis; cardiomyopathy; pulmonary hypertension
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Heart failure is a serious disease that is increasing worldwide. The diagnosis and treatment of myocardial diseases such as cardiomyopathy and myocarditis, which are among the causative diseases of heart failure, are important. Recent advances in molecular and cellular biological understandings of the causes and pathophysiology of these diseases have led to the development of diagnostic methods and specific treatments.

Treatment methods based on the pathophysiology of hypertrophic cardiomyopathy, Fabry disease, and amyloidosis have been proposed and implemented in practice. Further developments in diagnostic and therapeutic methods in various cardiomyopathies, such as dilated cardiomyopathy and arrhythmogenic right ventricular cardiomyopathy, are expected in the future. In myocarditis and sarcoidosis, the involvement of immunity and cytokines is being elucidated, and further therapeutic advances are expected in the future. The development of tailor-made medicine based on genetic abnormalities and differences in immune and inflammatory mechanisms is awaited.

This Special Issue entitled “Myocardial Disease: Molecular Pathology and Treatments” welcomes original research and reviews of the literature concerning this important topic. Since IJMS is a journal of molecular science, pure clinical or model studies will not suitable for our journal. However, clinical or pure model submissions with biomolecular experiments are welcomed.

Dr. Kazufumi Nakamura
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hypertrophic cardiomyopathy
  • dilated cardiomyopathy
  • arrhythmogenic right ventricular cardiomyopathy
  • amyloidosis
  • myocarditis
  • sarcoidosis
  • genetic abnormalities
  • immune mechanisms

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

21 pages, 22278 KiB  
Article
Distinctive Deposition Patterns of Sporadic Transthyretin-Derived Amyloidosis in the Atria: A Forensic Autopsy-Based Study
by Shojiro Ichimata, Yukiko Hata, Koji Yoshida, Keiichi Hirono and Naoki Nishida
Int. J. Mol. Sci. 2024, 25(15), 8176; https://doi.org/10.3390/ijms25158176 - 26 Jul 2024
Viewed by 415
Abstract
Left-to-right differences in the histopathologic patterns of transthyretin-derived amyloid (ATTR) deposition in the atria of older adults have not yet been investigated. Hence, this study evaluated heart specimens from 325 serial autopsy subjects. The amount of ATTR deposits in the seven cardiac regions, [...] Read more.
Left-to-right differences in the histopathologic patterns of transthyretin-derived amyloid (ATTR) deposition in the atria of older adults have not yet been investigated. Hence, this study evaluated heart specimens from 325 serial autopsy subjects. The amount of ATTR deposits in the seven cardiac regions, including both sides of atria and atrial appendages, was evaluated semiquantitatively. Using digital pathology, we quantitatively evaluated the immunohistochemical deposition burden of ATTR in the myocardium. We identified 20 sporadic ATTR cardiac amyloidosis cases (nine males). All patients had ATTR deposition in the left atrial regions of the myocardium. In the semiquantitative analysis, 14 of the 20 cases showed more severe ATTR deposition on the left atrial regions than on the right side, with statistically significant differences in the pathology grading (p < 0.01 for both the atrium and atrial appendage). Quantitative analysis further supported the difference. Moreover, six had ATTR deposition in the epineurium and/or neural fibers of the atria. Cluster analysis revealed that ATTR deposition in the myocardium was significantly more severe in males than in females. The heterogeneous distribution of amyloid deposits between atria revealed in this study may impair the orderly transmission of the cardiac conduction system and induce arrhythmias, which may be further aggravated by additional neuropathy in the advanced phase. This impairment could be more severe among males. These findings emphasize that atrial evaluation is important for individuals with sporadic ATTR cardiac amyloidosis, particularly for early detection. Full article
(This article belongs to the Special Issue Myocardial Disease: Molecular Pathology and Treatments)
Show Figures

Graphical abstract

Back to TopTop