Novel MSC Perspectives: From Cell Regulation to Tissue Regeneration

Dear Colleagues,

The development in understanding mesenchymal stem cell (MSC) biology, gene regulation and intercellular interactions is holding promise for the evolution of therapeutic approaches in tissue regeneration, both in humans and in animals. For their exclusive capacity to self renew and commitment towards defined cell lineages, MSCs offer novel perspectives and tools for clinical application in a safe and effective manner. Recent knowledge in the crosstalk between MSCs and the microenvironment has highlighted that key soluble modulators, specific signaling pathways and/or the employment of biomaterials are able to foster a wide array of MSC properties including migration, behavior and also gene expression and cell fate. This provides new insights for the genetic manipulation, reprogramming and/or gene editing of MSCs addressing also physical, biological and biochemical properties of MSCs in order to boost their regenerative capabilities and tissue repair. Finally, studies concerning the use of MSCs from different sources for tissue regeneration in pre-clinical and clinical applications will allow to translate the knowledge on MSC functions “from the bench to the bedside”. Accordingly, we invite investigators to contribute with novel findings in the field of MSCs and therefore helping to bridge the gap between biology of regeneration and regenerative medicine and to encourage a novel progression towards the MSC-based translational research.

Gruppo Italiano Staminali Mesenchimali (GISM)

Prof. Dr. Heba Abdelrazik
Dr. Giovanni Barbanti-Bròdano
Prof. Dr. Elena De Falco
Prof. Dr. Emanuele Giordano
Prof. Dr. Alessandra Pelagalli
Guest Editors

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