Nutrigenomics in Liver Diseases: An Uncharted Territory

Dear Colleagues,

Evidence indicates that metabolic disorders develop as a result of a complex interaction between genetics and environmental factors. Furthermore, epigenetic changes such as DNA-methylation and microRNAs, which regulate the liver transcriptome, concur with environmental factors with regard to liver disease onset. The interface between nutritional environment and cellular/genetic processes is referred to as nutritional genomics or “nutrigenomics”. In recent years, nutrigenomics has contributed to our understanding of how nutrition affects the decline from health to disease by modulating the expression of an individual’s genetic makeup.

Papers submitted to this Special Issue must be focused upon the interaction between genetic background and diet with regard to the development of metabolic diseases and related comorbidities, which deepen the mechanisms through which nutrients and dietary patterns may alter the epigenome. Indeed, individuals vary in their nutrient requirements and responses to diet according to their genetic features, and epigenetic changes can be prevented and manipulated by dietary factors, suggesting that personalized nutrition may represent an important individualistic therapeutic approach to liver diseases and their complications.

Dr. Paola Dongiovanni
Guest Editor

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