Peroxisomes under the Spotlight: Collaboration is the Way to Go
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (30 June 2019) | Viewed by 68010
Special Issue Editor
Interests: molecular biology, biochemistry, and function of peroxisomes; peroxisomal disorders; inter-organelle crosstalk; mitochondria; oxidative stress; redox signaling; monitoring and modulation of the intracellular redox state at the subcellular level; intracellular protein trafficking; pulse labeling of proteins; protein–protein interactions
Special Issue Information
Dear Colleagues,
In 2019, it will be 65 years since the Swedish doctoral student Johannes Rhodin described, for the first time, the existence of special organelles, currently known as peroxisomes, in mouse kidney cells. After being overlooked for a long time, this organelle has now moved into the spotlight of cell biology, biomedical research, and biotechnology. Peroxisomes are remarkably dynamic organelles whose functions can differ substantially across different species, life stages, and environmental conditions. To maintain their function and dynamics, these organelles must exchange substrates, metabolites, and signaling molecules with other subcellular compartments. This is thought to occur via vesicular traffic, membrane contact sites, and membrane transport proteins. Dysregulation of any of these processes has been demonstrated to impact organismal fitness and survival.
This Special Issue aims to provide a forum for researchers around the world to share their latest findings and views on how peroxisomes communicate with their environment to support cellular functions. Potential topics include, but are not limited to, the molecular, biochemical, and cellular mechanisms that control peroxisome dynamics and functions in various organisms and disease states. Both original research articles and review papers that stimulate discussion are welcome.
Prof. Dr. Marc Fransen
Guest Editor
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Keywords
- peroxisome
- organelle communication
- contact site
- membrane transporter
- signaling messenger
- lipid metabolism
- redox metabolism
- organelle dysfunction
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