Polyphenols and Neurodegenerative Disorders
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".
Deadline for manuscript submissions: closed (30 January 2023) | Viewed by 2023
Special Issue Editor
Interests: medicinal chemistry phytochemical; natural and synthetic molecules; mechanisms to defeat dementia; Alzheimer’s disease; brain-gut axis; dietary directions against dementia; lifestyle modifications
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
For the future of humanity, there are 86 billion neurons/reasons why it is important to study the medicinal and nutritional science of neurodegeneration. With the global aging population increasing, the suffering from dementia is anticipated to rise to over 152 million by 2050. Alzheimer’s disease, that is the foremost widespread dementia is a progressive age-risk-related disorder of the brain cortex and hippocampus regions, and involves the cognitive impairment along with reduced capacity/function. Dietary polyphenols are one of the most abundant types of plant secondary metabolites. Fruit and vegetables are rich sources of bioactive constituents that contribute to human health and experimental and epidemiological data indicates a function for polyphenols in the prevention of chronic diseases such as cardiovascular, type 2 diabetes, certain cancers and neuropathologies. Currently there is no definitive evidence from human studies or clinical trials that nutrient/lifestyle factors can modify cognitive disorders, or are neuroprotective against neurodegeneration. We know there are new discoveries on the horizon because poor nutrition impairs learning, memory and lifespan. Healthy lifestyles and dietary polyphenol patterns, a plant based meal plan is recommended that works for neuroprotection. This Special Issue concerns with the biomolecular mechanisms of dietary polyphenols, essential knowledge in order to understand neurodegenerative disorders. Happy to receive your research articles, suggested topics include: 1) therapeutic efficacy, multiple mechanisms of polyphenols as neuroprotective agents; 2) what future implications dietary fruits and vegetables and lifestyles may have on overcoming neurodegenerative diseases; 3) the most effective flavonoids that improve cognitive function, blood pressure, metabolic profile; 4) the role of flavonoids in age-related neurodegenerative disorders that relate to vascular pathology; 5) mechanisms of polyphenol microbial metabolites as neuroprotective agents; 6) polyphenol modulation of signaling pathways, epigenetic mechanisms.
Dr. Helmut M. Hugel
Guest Editor
Manuscript Submission Information
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Keywords
- dietary polyphenols
- fruits & vegetables
- therapeutic efficacy
- neurodegenerative disorders
- neuroprotection
- cognition enhancing
- microbial metabolites
- signaling pathways
- autophagy
- vascular pathology
- biomolecular mechanisms
