Phytochemicals in Neuroprotection
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".
Deadline for manuscript submissions: closed (28 July 2023) | Viewed by 5475
Special Issue Editor
Interests: medicinal chemistry phytochemical; natural and synthetic molecules; mechanisms to defeat dementia; Alzheimer’s disease; brain-gut axis; dietary directions against dementia; lifestyle modifications
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The brain and body are living laboratories of biosynthesis, metabolism, and catabolism, whereby aging laboratories require increased maintenance to sustain homeostasis and optimal function. Chemistry permeates life and nature, but nature is the best chemist; therefore, a class of molecules that treats multiple age-related diseases would have a major impact on global healthy aging and economics. Phytochemicals and related natural products abundant in foods, beverages and herbs are arguably the most promising family of preventative and protective compounds to alleviate symptoms of multiple diseases or disabilities of human aging. Since human health benefits are influenced by lifestyles, the dietary intake and body–brain interactions of phytochemicals that are abundant in fruits, berries, vegetables, herbs, and beverages are a resource that can provide opportunities for intervention and protection strategies against Alzheimer’s and other neurodegenerative diseases. The science of the molecular mechanisms and metabolic processes of phytochemical consumption occurring in the body and brain can direct, determine and provide new strategies of how to optimize and select constituents that may sustainably provide generic benefits for neurons to defend against insults.
This Special Issue provides insights into the molecular episodes of phytochemicals that can be used to unlock their full translational biochemical health potential for human needs. This also affords an intellectual framework and platform for the design/discovery of more potent products that could potentially become available and be directed towards providing health-sustaining interventions against aging brain diseases.
This Special Issue concerns and revolves around the science and impact of phytochemicals on aging and lifestyles. Some examples include:
- Aging: Aging and tea consumption and risk of dementia
- Diet: For example, the effect of the MIND diet of obese persons on cognition; chocolate and better health; the effect of berry-based supplements and foods on cognitive function; fruits and vegetables high in polyphenolics can prevent and even reverse age-related cognitive deficits
- Exercise: Physical activity and fruit, vegetable consumption, decreases risk of depression by 80%; clustering recapitulates the stimulating effects of exercise on hippocampal cell genesis and memory; exercise training improves memory
- Neuroprotection: Effects of phytochemical protection on the body and brain; the mitophagy modulator polyphenols kaempferol and rhapontigenin improve neuroprotection.
Dr. Helmut M. Hugel
Guest Editor
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Keywords
- dietary phytochemicals
- fruits & vegetables
- therapeutic efficacy
- neurodegenerative disorders
- neuroprotection
- cognition enhancing
- microbial metabolites
- signaling pathways
- autophagy
- vascular pathology
- biomolecular mechanisms
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