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Precision Medicine for Oral Diseases and Cancers
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Precision Medicine for Oral Diseases and Cancers

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".

Deadline for manuscript submissions: 20 March 2025 | Viewed by 4901

Special Issue Editors

Prof. Dr. Marina Di Domenico

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Guest Editor
Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
Interests: cancer; laboratory medicine; personalized medicine; diagnostic; microbiota
Prof. Dr. Andrea Ballini

E-Mail Website
Guest Editor
Department of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, Italy
Interests: scientific research activity in dentistry; stem cells and regenerative medicine; oral microbiology; public health and preventive medicine; biotechnology; translational medicine and dental hygiene
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Precision medicine has emerged as a powerful model that focuses on how biomolecular factors can influence individual responses to different medications/therapies affecting drug efficacy, side effects and adverse events related to therapy. The long-term goal of the research being conducted is the identification of responders and non-responders to therapy and, thus, the avoidance of adverse events and the optimization of drug/therapeutic doses. The study of the molecular and cellular mechanisms that regulate complex systems requires an intense interaction between basic and applied research. Translational medicine combines biomedical skills and advancements in basic research with clinical reality.

Suitable topics include, but are not limited to, the following: translational research, precision/personalized medicine stem cells, bioscaffolds, biomedical devices, health informatics, bioinformatics, biotechnology, biomechanics, computational mechanobiology, microbiota, and the role of oral health and disease on contributing to general health and systemic conditions. The main focus is on novel developments and applications in precision medicine and relevant themes. We especially encourage the submission of interdisciplinary work research and welcome submissions of original research papers using different study designs and critical and relevant reviews.

Prof. Dr. Marina Di Domenico
Dr. Andrea Ballini
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer
  • laboratory medicine
  • personalized medicine
  • diagnostic
  • machine learning
  • precision medicine
  • stem cells
  • oral diseases
  • clinical biochemistry
  • translational medicine
  • geometry optimization of biomaterials
  • cell adhesion
  • computational mechanobiology
  • bioengineering
  • bioscaffolds
  • systemic diseases
  • general health
  • quality of life
  • microbiota

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Published Papers (3 papers)

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Research

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12 pages, 3369 KiB  
Article
The Dynamics of OXA-23 β-Lactamase from Acinetobacter baumannii
by Roberto Arrigoni, Andrea Ballini, Luigi Santacroce and Luigi Leonardo Palese
Int. J. Mol. Sci. 2023, 24(24), 17527; https://doi.org/10.3390/ijms242417527 - 15 Dec 2023
Cited by 2 | Viewed by 1750
Abstract
Antibiotic resistance is a pressing topic, which also affects β-lactam antibiotic molecules. Until a few years ago, it was considered no more than an interesting species from an academic point of view, Acinetobacter baumanii is today one of the most serious threats [...] Read more.
Antibiotic resistance is a pressing topic, which also affects β-lactam antibiotic molecules. Until a few years ago, it was considered no more than an interesting species from an academic point of view, Acinetobacter baumanii is today one of the most serious threats to public health, so much so that it has been declared one of the species for which the search for new antibiotics, or new ways to avoid its resistance, is an absolute priority according to WHO. Although there are several molecular mechanisms that are responsible for the extreme resistance of A. baumanii to antibiotics, a class D β-lactamase is the main cause for the clinical concern of this bacterial species. In this work, we analyzed the A. baumanii OXA-23 protein via molecular dynamics. The results obtained show that this protein is able to assume different conformations, especially in some regions around the active site. Part of the OXA-23 protein has considerable conformational motility, while the rest is less mobile. The importance of these observations for understanding the functioning mechanism of the enzyme as well as for designing new effective molecules for the treatment of A. baumanii is discussed. Full article
(This article belongs to the Special Issue Precision Medicine for Oral Diseases and Cancers)
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Review

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14 pages, 555 KiB  
Review
Treatment of Oroantral Communication and Fistulas with the Use of Blood-Derived Platelet-Rich Preparations Rich in Growth Factors: A Systematic Review
by Paulina Adamska, Magdalena Kaczoruk-Wieremczuk, Dorota Pylińska-Dąbrowska, Marcin Stasiak, Michał Bartmański, Adam Zedler and Michał Studniarek
Int. J. Mol. Sci. 2024, 25(21), 11507; https://doi.org/10.3390/ijms252111507 - 26 Oct 2024
Viewed by 855
Abstract
The formation of an oroantral communication (OAC) or fistula (OAF) is a rare complication resulting from the presence of processes in the lateral parts of the maxilla or for iatrogenic reasons. The most common causes of OAC or OAF are tooth extraction with [...] Read more.
The formation of an oroantral communication (OAC) or fistula (OAF) is a rare complication resulting from the presence of processes in the lateral parts of the maxilla or for iatrogenic reasons. The most common causes of OAC or OAF are tooth extraction with periapical lesions. The aims of this systematic review were to assess the use of platelet-derived preparations rich in growth factors in the treatment of OAC or OAF, to determine the success of treating the communication or fistula, as well as impact on postoperative complications and the course of healing. The study was performed following PRISMA guidelines (PROSPERO: CRD42024570758). The inclusion criteria were as follows: at least ten patients, the presence of oroantral communication or oroantral fistula, treatment with platelet-derived preparations rich in growth factors, and information regarding the response to treatment. In order to find relevant studies, international databases, including PubMed, Google Scholar, Web of Science Core Collection, MDPI, Wiley, and Cochrane Library were searched. The last search was performed on 31 August 2024. Seven articles were included in the systematic review. In total, platelet-derived preparations rich in growth factors were used in 164 patients. Only studies in which OAC was treated and with platelet-rich fibrin (PRF) met the inclusion criteria. Only PRF was used as the sole treatment method in three studies. When OAC is greater than 5 mm, platelet-derived preparations rich in growth factors should be considered adjuncts to treatment, not the sole treatment method. The success rate of OAC treatment was 90–100%. The use of blood products to close OAC may be an effective therapeutic alternative. Proper patient qualification and the use of an appropriate protocol are crucial. There is a need for future well-designed case-control or cohort studies as well as randomized controlled trials to provide the required level of evidence. Full article
(This article belongs to the Special Issue Precision Medicine for Oral Diseases and Cancers)
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Other

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13 pages, 13195 KiB  
Case Report
Treatment of Odontogenic Maxillary Sinusitis with the Use of Growth Factors in Advanced Platelet-Rich Fibrin for Immediate Closure of Oro-Antral Communication: A Case Report
by Paulina Adamska, Dorota Pylińska-Dąbrowska, Marcin Stasiak, Magdalena Kaczoruk-Wieremczuk, Ewa Kozłowska, Adam Zedler and Michał Studniarek
Int. J. Mol. Sci. 2024, 25(8), 4339; https://doi.org/10.3390/ijms25084339 - 14 Apr 2024
Cited by 1 | Viewed by 1809
Abstract
Chronic odontogenic maxillary sinusitis (COMS), a prolonged inflammation of the maxillary sinus lasting over 12 weeks, is often a result of periapical lesions, marginal periodontitis, and complications like oro-antral communication (OAC) and fistula (OAF). OAC, commonly emerging post-teeth extraction in the lateral maxilla, [...] Read more.
Chronic odontogenic maxillary sinusitis (COMS), a prolonged inflammation of the maxillary sinus lasting over 12 weeks, is often a result of periapical lesions, marginal periodontitis, and complications like oro-antral communication (OAC) and fistula (OAF). OAC, commonly emerging post-teeth extraction in the lateral maxilla, lacks documented treatments using advanced platelet-rich fibrin (A-PRF). This study evaluates A-PRF’s efficacy in treating COMS and immediately sealing extensive OAC. A case of a 28-year-old male with COMS linked to a periapical lesion and supernumerary molars is presented. Treatment involved extracting specific teeth while preserving adjacent ones and using A-PRF for immediate OAC closure. A-PRF, enriched with growth factors, was pivotal in healing, showcasing enhanced tissue regeneration, pain reduction, and faster recovery. The findings suggest A-PRF as an effective adjunct in treating extensive OAC and COMS, proposing its inclusion in standard treatment protocols. This study underscores A-PRF’s potential in improving outcomes for patients with COMS and related complications. Full article
(This article belongs to the Special Issue Precision Medicine for Oral Diseases and Cancers)
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