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Redox Balance and Materials Used in the Treatment of Craniofacial Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (31 August 2022) | Viewed by 4909

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Experimental Dentistry Laboratory, Medical University, Białystok, Poland
Interests: saliva; redox balance; oxidative stress
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Special Issue Information

Dear Colleagues,

Oxygen- and nitrogen-free radicals have a beneficial effect on wound healing and immune response generation and exhibit antibacterial, antivirus and antifungus properties, which are extremely important in the treatment of the diseases of the head and neck area. On the other hand, excessive generation of oxygen/nitrogen-free radicals, while disturbing the balance between their production and neutralization, leads to oxidative damage of cellular proteins, lipids, and nucleic acids. This pathological process is responsible for impairment of the tissue and organ function through its impact on gene expression and cell signaling pathways, growth, differentiation, proliferation, and cell apoptosis. The craniofacial area, including the oral cavity, is subjected to many environmental pro-oxidative factors, and ROS may be a byproduct of resin cements, lasers, endodontic and periodontological treatments, implant, bleaching, inflammation, and anticancer therapies in the head and neck area and many other techniques and therapeutic materials.

We kindly invite researchers to submit original research and review articles on the subject of redox balance and materials used in the treatment of craniofacial diseases, including those located in the oral cavity. Your publication in this Special Issue will allow for your research to be disseminated to a wide range of outstanding scientists.

Prof. Dr. Anna Zalewska
Guest Editor

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Keywords

  • antioxidants
  • bleaching agents
  • cancers treatment
  • composites
  • intracanal medicaments
  • ionizing radiation
  • lasers
  • implants
  • oxidative modification products
  • oxidative stress
  • periodontal treatments
  • resin cement
  • ultraviolet rays

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Published Papers (1 paper)

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Review

27 pages, 766 KiB  
Review
The Effect of Selected Dental Materials Used in Conservative Dentistry, Endodontics, Surgery, and Orthodontics as Well as during the Periodontal Treatment on the Redox Balance in the Oral Cavity
by Izabela Zieniewska, Mateusz Maciejczyk and Anna Zalewska
Int. J. Mol. Sci. 2020, 21(24), 9684; https://doi.org/10.3390/ijms21249684 - 18 Dec 2020
Cited by 27 | Viewed by 4473
Abstract
Oxidative stress (OS) is a redox homeostasis disorder that results in oxidation of cell components and thus disturbs cell metabolism. OS is induced by numerous internal as well as external factors. According to recent studies, dental treatment may also be one of them. [...] Read more.
Oxidative stress (OS) is a redox homeostasis disorder that results in oxidation of cell components and thus disturbs cell metabolism. OS is induced by numerous internal as well as external factors. According to recent studies, dental treatment may also be one of them. The aim of our work was to assess the effect of dental treatment on the redox balance of the oral cavity. We reviewed literature available in PubMed, Medline, and Scopus databases, including the results from 2010 to 2020. Publications were searched according to the keywords: oxidative stress and dental monomers; oxidative stress and amalgam; oxidative stress and periodontitis, oxidative stress and braces, oxidative stress and titanium; oxidative stress and dental implants, oxidative stress and endodontics treatment, oxidative stress and dental treatment; and oxidative stress and dental composite. It was found that dental treatment with the use of composites, amalgams, glass-ionomers, materials for root canal filling/rinsing, orthodontic braces (made of various metal alloys), titanium implants, or whitening agents can disturb oral redox homeostasis by affecting the antioxidant barrier and increasing oxidative damage to salivary proteins, lipids, and DNA. Abnormal saliva secretion/composition was also observed in dental patients in the course of OS. It is suggested that the addition of antioxidants to dental materials or antioxidant therapy applied during dental treatment could protect the patient against harmful effects of OS in the oral cavity. Full article
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